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DOI	10.1016/j.marpolbul.2018.12.029
	Essential element Cu and non-essential element Hg exposures have different toxicological effects in the liver of large yellow croaker
	Zeng L.; Ai C.; Zhang J.; Zheng J.
发表日期	2019
ISSN	0025326X
起始页码	6
结束页码	13
卷号	139
英文摘要	The objective was to compare the different effects of essential element Cu and non-essential element Hg on antioxidant and inflammatory responses in the liver of large yellow croaker Larimichthys crocea. Fish were exposed to Cu stresses (72 and 288 μg L−1) and Hg stresses (14 and 56 μg L−1) for 96 h. High-dose Cu increased metallothioneins (MTs) levels and immune defenses in response to elevated reactive oxygen species (ROS), but low-dose Cu had no effect on ROS. High-dose Hg reduced antioxidant and inflammatory responses, which contributed to the increment of ROS. MTs may be a suitable biomarker to assess Cu contamination, but no relationship was observed between MTs levels and Hg content. Furthermore, NFE2-related nuclear factor 2 (Nrf2) and nuclear transcription factor κB (NF-κB) were positively related to their respective target genes in the Cu-exposed groups. In conclusion, Cu and Hg induced some differences in antioxidant and inflammatory responses, which providing some novel insights into toxicological effects of Cu and Hg stresses. © 2018
英文关键词	Inflammatory response; Larimichthys crocea; Metal exposure; Oxidative stress
语种	英语
scopus关键词	Oxidative stress; Transcription; Different effects; Essential elements; Inflammatory response; Larimichthys crocea; Metal exposures; Nuclear transcription factors; Reactive oxygen species; Toxicological effects; Antioxidants; biological marker; copper; immunoglobulin enhancer binding protein; mercury; metallothionein; reactive oxygen metabolite; transcription factor Nrf2; antioxidant; biological marker; copper; fish protein; mercury; metallothionein; reactive oxygen metabolite; copper; heavy metal; mercury (element); oxidative stress; perciform; pollution exposure; reactive oxygen species; toxicology; animal experiment; animal model; animal tissue; antioxidant activity; Article; biochemical analysis; contamination; controlled study; gene targeting; inflammation; innate immunity; Larimichthys crocea; liver toxicity; long term exposure; nonhuman; oxidative stress; Sciaenidae; animal; dose response; drug effect; environmental monitoring; genetics; liver; metabolism; Perciformes; procedures; theoretical model; toxicity; water pollutant; Pseudosciaena crocea; Animals; Antioxidants; Biomarkers; Copper; Dose-Response Relationship, Drug; Environmental Monitoring; Fish Proteins; Liver; Mercury; Metallothionein; Models, Theoretical; Oxidative Stress; Perciformes; Reactive Oxygen Species; Water Pollutants, Chemical
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/150174
作者单位	National Engineering Research Center of Marine Facilities Aquaculture, Zhejiang Ocean University, Zhoushan, 316022, China; College of Ocean and Earth Sciences, Xiamen University, Xiamen, 361005, China
推荐引用方式 GB/T 7714	Zeng L.,Ai C.,Zhang J.,et al. Essential element Cu and non-essential element Hg exposures have different toxicological effects in the liver of large yellow croaker[J],2019,139.
APA	Zeng L.,Ai C.,Zhang J.,&Zheng J..(2019).Essential element Cu and non-essential element Hg exposures have different toxicological effects in the liver of large yellow croaker.Marine Pollution Bulletin,139.
MLA	Zeng L.,et al."Essential element Cu and non-essential element Hg exposures have different toxicological effects in the liver of large yellow croaker".Marine Pollution Bulletin 139(2019).