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DOI	10.1016/j.marpolbul.2019.02.042
	Effect of P-glycoprotein regulation on cadmium exhaustion from Crassostrea gigas
	Yang C.; Liu Q.; Li G.; Meng X.; Liu B.
发表日期	2019
ISSN	0025326X
起始页码	307
结束页码	312
卷号	141
英文摘要	P-glycoprotein (P-gp) is a molecular pump, responsible for extruding xenobiotics. The aim of the study was to demonstrate the role of P-glycoprotein (P-gp) in cadmium (Cd) exhaustion. The activity of P-gp was regulated in Crassostrea gigas, which was previously exposed to Cd by using rifampicin (inducer) and verapamil (inhibitor), respectively. Comparing with Crassostrea gigas depurated in natural seawater, Cd content increased significantly from 14.28 mg/kg dw to 17.49 mg/kg dw accompanied by a changed metallothionein level from 9.84 μg/g fw to 10.67 μg/g fw after 25 μg/L verapamil treatment, while Cd content after 25 μg/L rifampicin treatment reduced to 12.21 mg/kg dw. Moreover, after treatment with rifampicin and verapamil, beneficial metal elements, fats, and proteins were maintained, and the tissue-dependent difference was found in the variation of antioxidant defenses and oxidative damage in Crassostrea gigas. In brief, the study provided new evidence on possibility of Cd removal by inducing P-glycoprotein. © 2019 Elsevier Ltd
英文关键词	Cadmium; Crassostrea gigas; Exhaustion; P-glycoprotein; Rifampicin induce
语种	英语
scopus关键词	Biochemistry; Cadmium; Antioxidant defense; Crassostrea gigas; Exhaustion; Metallothioneins; Molecular pumps; Oxidative damage; P-glycoprotein; Rifampicin induce; Glycoproteins; ABC transporter subfamily B; metallothionein; rifampicin; sea water; verapamil; antioxidant; cadmium; metallothionein; rifampicin; verapamil; antibiotics; cadmium; inhibitor; metallothionein; mollusc; protein; xenobiotics; Article; bioaccumulation; cadmium exhaustion; controlled study; Crassostrea gigas; lipid metabolism; nonhuman; oxidative stress; protein function; protein metabolism; regulatory mechanism; xenobiotic metabolism; animal; antagonists and inhibitors; chemistry; Crassostrea; drug effect; drug inactivation; metabolism; tissue distribution; toxicity; water pollutant; Crassostrea gigas; Animals; Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cadmium; Crassostrea; Inactivation, Metabolic; Metallothionein; Rifampin; Seawater; Tissue Distribution; Verapamil; Water Pollutants, Chemical
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/150022
作者单位	College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China
推荐引用方式 GB/T 7714	Yang C.,Liu Q.,Li G.,et al. Effect of P-glycoprotein regulation on cadmium exhaustion from Crassostrea gigas[J],2019,141.
APA	Yang C.,Liu Q.,Li G.,Meng X.,&Liu B..(2019).Effect of P-glycoprotein regulation on cadmium exhaustion from Crassostrea gigas.Marine Pollution Bulletin,141.
MLA	Yang C.,et al."Effect of P-glycoprotein regulation on cadmium exhaustion from Crassostrea gigas".Marine Pollution Bulletin 141(2019).