气候变化领域集成服务门户(CCPortal): Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna

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DOI	10.1016/j.marpolbul.2019.02.065
	Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna
	Cortez F.S.; Souza L.D.S.; Guimarães L.L.; Pusceddu F.H.; Maranho L.A.; Fontes M.K.; Moreno B.B.; Nobre C.R.; Abessa D.M.D.S.; Cesar A.; Pereira C.D.S.
发表日期	2019
ISSN	0025326X
起始页码	366
结束页码	372
卷号	141
英文摘要	Concerns are growing about the presence of fluoxetine (FLX) in environmental matrices, as well as its harmful effects on non-target organisms. FLX in aquatic ecosystems has been detected in a range varying from pg/L to ng/L, while adverse effects have been reported in several organisms inhabiting freshwater and marine environments. The present study quantifies FLX concentrations in seawater samples from Santos Bay, Brazil and assesses metabolic responses and sublethal effects on the tropical brown mussel Perna perna. Levels of ethoxyresorufin‑O‑deethylase, dibenzylfluorescein dealkylase, glutathione S-transferase, glutathione peroxidase, cholinesterase, lipoperoxidation, and DNA damage were assessed in the gills and digestive gland of these animals, and lysosomal membrane stability was also assessed in hemocytes. FLX altered phase I and II enzyme activities, caused cytogenotoxic effects, and negatively impacted the overall health of mussels exposed to environmentally relevant concentrations. These findings contribute to characterize the risks of introducing this drug into the marine environment. © 2019 Elsevier Ltd
英文关键词	Antidepressants; Bivalves; Brazil; Contaminants of emerging concern; Tropical ecotoxicology
语种	英语
scopus关键词	Aquatic ecosystems; Damage detection; Marine pollution; Molluscs; Peptides; Tropics; Antidepressants; Bivalves; Brazil; Contaminants of emerging concerns; Eco-toxicology; Seawater effects; cholinesterase; ethoxyresorufin deethylase; fluoxetine; glutathione peroxidase; glutathione transferase; sea water; unclassified enzyme; biological marker; fluoxetine; bivalve; chemical pollutant; ecosystem response; environmental risk; enzyme activity; genotoxicity; marine environment; marine pollution; nontarget organism; sublethal effect; water pollution; Article; blood cell; Brazil; controlled study; DNA damage; enzyme activity; exocrine gland; genotoxicity; gill; lipid peroxidation; lysosome membrane; metabolism; nonhuman; Perna perna; toxic concentration; water contamination; water sampling; analysis; animal; chemistry; cytology; digestive system; DNA damage; drug effect; genetics; Perna; toxicity; tropic climate; water pollutant; Brazil; Animalia; Bivalvia; Perna perna; Animals; Biomarkers; Brazil; Digestive System; DNA Damage; Fluoxetine; Gills; Hemocytes; Perna; Seawater; Tropical Climate; Water Pollutants, Chemical
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/150015
作者单位	Universidade Santa Cecília, Rua Oswaldo Cruz 266, Santos, SP 11045-907, Brazil; Universidade Estadual Paulista Júlio de Mesquita, Pr. Infante Dom Henrique, s/n, São Vicente, 11330-900, Brazil; Universidad de Cádiz, Polígono Río San Pedro, s/n, Puerto Real, 11510, Spain; Universidade Federal de São Paulo, Rua Maria Máximo 168, Santos, SP 11030-100, Brazil
推荐引用方式 GB/T 7714	Cortez F.S.,Souza L.D.S.,Guimarães L.L.,et al. Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna[J],2019,141.
APA	Cortez F.S..,Souza L.D.S..,Guimarães L.L..,Pusceddu F.H..,Maranho L.A..,...&Pereira C.D.S..(2019).Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna.Marine Pollution Bulletin,141.
MLA	Cortez F.S.,et al."Marine contamination and cytogenotoxic effects of fluoxetine in the tropical brown mussel Perna perna".Marine Pollution Bulletin 141(2019).