气候变化领域集成服务门户(CCPortal): Arctic marine fish ‘biotransformation toxicity’ model for ecological risk assessment

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DOI	10.1016/j.marpolbul.2019.03.039
	Arctic marine fish ‘biotransformation toxicity’ model for ecological risk assessment
	Fahd F.; Veitch B.; Khan F.
发表日期	2019
ISSN	0025326X
起始页码	408
结束页码	418
卷号	142
英文摘要	Oil and gas exploration and marine transport in the Arctic region have put the focus on the ecological risk of the possibly exposed organisms. In the present study, the impacts of sea ice, extreme light regime, various polar region-specific physiological characteristics in polar cod (Boreogadus saida) and their effects on xenobiotic distribution and metabolism are studied. A Bayesian belief network is used to model individual fish toxicity. The enzyme activity in the fish liver and other pertinent organs is used as a proxy for cellular damage and repair and is subsequently linked to toxicity in polar cod. Seasonal baseline variation in enzyme production is also taken into consideration. The model estimates the probability of exposure concentration to cause cytotoxicity and circumvents the need to use the traditionally obtained No Observed Effect Concentration (NOEC). Instead, it uses biotransformation enzyme activity as a basis to estimate the probability of individual cell damages. © 2019 Elsevier Ltd
英文关键词	Arctic risk; Biotransformation toxicity; Ecological risk; Marine risk; Oil spill; Toxicodynamics; Toxicokinetics
语种	英语
scopus关键词	Bayesian networks; Bioconversion; Enzyme activity; Fish; Marine pollution; Offshore gas fields; Oil spills; Petroleum prospecting; Petroleum transportation; Sea ice; Toxicity; Biotransformation enzymes; Ecological risk assessment; Ecological risks; No-observed-effect-concentrations; Oil and gas exploration; Physiological characteristics; Toxicodynamics; Toxicokinetics; Risk assessment; biotransformation; ecotoxicology; environmental assessment; environmental risk; enzyme; marine pollution; metabolism; oil spill; pollution effect; animal cell; animal experiment; animal model; animal tissue; Arctic Ocean; Article; biological model; biotransformation; Boreogadus saida; cell damage; cell regeneration; controlled study; cytotoxicity; enzyme activity; enzyme synthesis; fish; light exposure; liver tissue; no-observed-adverse-effect concentration; nonhuman; risk assessment; sea ice; toxicity; xenobiotic metabolism; animal; Arctic; Bayes theorem; biotransformation; drug effect; ecotoxicology; Gadiformes; liver; metabolism; oil spill; pharmacokinetics; physiology; procedures; risk assessment; season; theoretical model; water pollutant; Arctic; Boreogadus saida; environmental marker; enzyme; polycyclic aromatic hydrocarbon; xenobiotic agent; Animals; Arctic Regions; Bayes Theorem; Biotransformation; Ecotoxicology; Environmental Biomarkers; Enzymes; Gadiformes; Liver; Models, Theoretical; Petroleum Pollution; Polycyclic Aromatic Hydrocarbons; Risk Assessment; Seasons; Water Pollutants, Chemical; Xenobiotics
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/149939
作者单位	Centre for Risk, Integrity and Safety Engineering (C-RISE), Faculty of Engineering and Applied Science, Memorial University of Newfoundland, St. John's, NL A1B 3X5, Canada
推荐引用方式 GB/T 7714	Fahd F.,Veitch B.,Khan F.. Arctic marine fish ‘biotransformation toxicity’ model for ecological risk assessment[J],2019,142.
APA	Fahd F.,Veitch B.,&Khan F..(2019).Arctic marine fish ‘biotransformation toxicity’ model for ecological risk assessment.Marine Pollution Bulletin,142.
MLA	Fahd F.,et al."Arctic marine fish ‘biotransformation toxicity’ model for ecological risk assessment".Marine Pollution Bulletin 142(2019).