气候变化领域集成服务门户(CCPortal): Associations between organohalogen exposure and thyroid- and steroid-related gene responses in St. Lawrence Estuary belugas and minke whales

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DOI	10.1016/j.marpolbul.2019.05.029
	Associations between organohalogen exposure and thyroid- and steroid-related gene responses in St. Lawrence Estuary belugas and minke whales
	Simond A.E.; Houde M.; Lesage V.; Michaud R.; Zbinden D.; Verreault J.
发表日期	2019
ISSN	0025326X
起始页码	174
结束页码	184
卷号	145
英文摘要	Elevated concentrations of persistent organic pollutants (POPs) and emerging halogenated flame retardants (HFRs) have been reported in tissues of the endangered St. Lawrence Estuary (Canada) beluga population as well as in minke whales visiting that same feeding area. This study examined the linkages between blubber concentrations of POPs and emerging HFRs, and transcription in skin of genes involved in the regulation of thyroid and steroid axes in belugas and minke whales from the St. Lawrence Estuary. In belugas, concentrations of PCBs, OCs and hexabromobenzene (HBB) were positively correlated with the transcription of thyroid- and/or steroid-related genes, while Dec-604 CB concentrations were negatively associated with the transcription of glucocorticoid and thyroid genes. In minke whales, PBDE concentrations changed positively with Esrβ transcript levels and HBB concentrations negatively with Nr3c1 transcripts. Present results suggest that several biological functions including reproduction and energetic metabolism may represent potential targets for organohalogens in these whales. © 2019 Elsevier Ltd
英文关键词	Cetacean; Flame retardant; Gene transcription; Organochlorine; Steroid; Thyroid
语种	英语
scopus关键词	Cell proliferation; Estuaries; Flame retardants; Polychlorinated biphenyls; Transcription; Cetacean; Gene transcriptions; Organochlorines; Steroid; Thyroid; Organic pollutants; flame retardant; hexabromobenzene; organohalogen derivative; steroid hormone; thyroid hormone; unclassified drug; xenobiotic agent; flame retardant; polychlorinated biphenyl; steroid; cetacean; concentration (composition); flame retardant; gene expression; organochlorine; PCP; persistent organic pollutant; pollution exposure; steroid; adult; animal tissue; Article; belugas wlahe; Cetacea; concentration (parameter); correlational study; environmental exposure; Esr beta geen; estuary; gene; hormone response; male; minke whale; nonhuman; Nr3c1 gene; skin biopsy; adipose tissue; analysis; animal; beluga whale; chemistry; drug effect; ecotoxicology; estuary; female; gene expression regulation; genetics; metabolism; Quebec; thyroid gland; toxicity; water pollutant; Canada; Quebec [Canada]; Saint Lawrence Estuary; Balaenoptera acutorostrata; Cetacea; Delphinapterus; Adipose Tissue; Animals; Beluga Whale; Ecotoxicology; Estuaries; Female; Flame Retardants; Gene Expression Regulation; Male; Minke Whale; Polychlorinated Biphenyls; Quebec; Steroids; Thyroid Gland; Water Pollutants, Chemical
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/149817
作者单位	Centre de recherche en toxicologie de l'environnement (TOXEN), Département des sciences biologiques, Université du Québec à Montréal, P.O. Box 8888, Succursale Centre-ville, Montreal, QC H3C 3P8, Canada; Environment and Climate Change Canada, 105 McGill Street, Montreal, QC H2Y 2E7, Canada; Maurice Lamontagne Institute, Fisheries and Oceans Canada, P.O. Box 1000, 850 route de la Mer, Mont-Joli, QC G5H 3Z4, Canada; Groupe de Recherche et d'Éducation sur les Mammifères Marins (GREMM), 870 avenue Salaberry, Bureau R24, Québec, QC G1R 2T9, Canada; Mériscope, 833 rue du Quai, Portneuf-sur-Mer, QC G0T 1P0, Canada
推荐引用方式 GB/T 7714	Simond A.E.,Houde M.,Lesage V.,et al. Associations between organohalogen exposure and thyroid- and steroid-related gene responses in St. Lawrence Estuary belugas and minke whales[J],2019,145.
APA	Simond A.E.,Houde M.,Lesage V.,Michaud R.,Zbinden D.,&Verreault J..(2019).Associations between organohalogen exposure and thyroid- and steroid-related gene responses in St. Lawrence Estuary belugas and minke whales.Marine Pollution Bulletin,145.
MLA	Simond A.E.,et al."Associations between organohalogen exposure and thyroid- and steroid-related gene responses in St. Lawrence Estuary belugas and minke whales".Marine Pollution Bulletin 145(2019).