气候变化领域集成服务门户(CCPortal): Subcellular metal distributions and metallothionein associations in rough-toothed dolphins (Steno bredanensis) from Southeastern Brazil

CCPortal

DOI	10.1016/j.marpolbul.2019.06.038
	Subcellular metal distributions and metallothionein associations in rough-toothed dolphins (Steno bredanensis) from Southeastern Brazil
	Monteiro F.; Lemos L.S.; de Moura J.F.; Rocha R.C.C.; Moreira I.; Di Beneditto A.P.; Kehrig H.A.; Bordon I.C.A.C.; Siciliano S.; Saint'Pierre T.D.; Hauser-Davis R.A.
发表日期	2019
ISSN	0025326X
起始页码	263
结束页码	273
卷号	146
英文摘要	Metals are subject to internal subcellular compartmentalization, altering their bioavailability. Thus, subcellular metal assessments are crucial in biomonitoring efforts. Metal distribution in three subcellular fractions (insoluble - ISF, thermolabile - TLF and thermostable - TSF) were determined by ICP-MS in Steno bredanensis specimens from Southeastern Brazil. Associations between metals, metallothionein (MT) and reduced glutathione (GSH) were also investigated. Differential metal-detoxification mechanisms were observed. MT detoxification was mostly noted for As, Cd, and Pb, while Cu, Cr, Hg, Ni, Se and Ti displayed lower MT-associations. Fe, Zn and Se, on the other hand, were poorly associated to MT, and mostly present in the ISF, indicating low bioavailability. This is the first report on subcellular Sn and Ti distribution in cetaceans and the first in this species in Brazil. Potential protective roles of essential metals against toxic elements are postulated. This study indicates that important biochemical detoxification information is obtained through subcellular fraction analyses in marine mammals. © 2019
英文关键词	Bioavailability; Cetaceans; Environmental contamination; Metal detoxification; Metalloproteins; Subcellular fractions
语种	英语
scopus关键词	Biochemistry; Detoxification; Mammals; Proteins; Bioavailability; Cetaceans; Environmental contamination; Metal detoxification; Metallo-proteins; Subcellular fractions; Metals; arsenic; cadmium; chromium; copper; glutathione; iron; lead; mercury; metal; metallothionein; nickel; selenium; titanium; zinc; heavy metal; metal; metallothionein; tin; bioavailability; cell; chemical pollutant; detoxification; dolphin; metal; metallothionein; accuracy; animal tissue; Article; bioavailability; Brazil; cell fractionation; cellular distribution; controlled study; detoxification; female; inductively coupled plasma mass spectrometry; kidney tissue; liver tissue; male; muscle tissue; nonhuman; toothed whale; animal; drug inactivation; environmental monitoring; metabolism; procedures; water pollutant; Brazil; Cetacea; Mammalia; Steno; Steno bredanensis; Animals; Brazil; Dolphins; Environmental Monitoring; Glutathione; Inactivation, Metabolic; Metallothionein; Metals; Metals, Heavy; Subcellular Fractions; Tin; Titanium; Water Pollutants, Chemical
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/149728
作者单位	Departamento de Química, Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio), Gávea, Rio de Janeiro, RJ 22453-900, Brazil; Escola Nacional de Saúde Pública (ENSP), Fiocruz, Av. Brasil, 4.365 – Manguinhos, Rio de Janeiro, RJ 21040-360, Brazil; Leibniz Center for Tropical Marine Ecology – ZMT, Systems Ecology Group, Fahrenheitstraße 6, Bremen, 28359, Germany; Universidade Estadual do Norte Fluminense, Laboratório de Ciências Ambientais, Campos dos Goytacazes, RJ 28013-602, Brazil; UNESP - Univ Estadual Paulista, Campus do Litoral Paulista, Núcleo de Estudos em Poluição e Ecotoxicologia Aquática (NEPEA), Praça Infante Dom Henrique s/n°, Parque Bitaru, São Vicente, SP CEP 11330-900, Brazil; Laboratório de Enterobactérias/IOC/Fiocruz, Pavilhão Rocha Lima, 3°. andar, Av. Brasil, 4.365 – Manguinhos, Rio de Janeiro, RJ 21040-900, Brazil; Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, 4.365, Manguinhos, Rio de Janeiro, 21040-360, Brazil
推荐引用方式 GB/T 7714	Monteiro F.,Lemos L.S.,de Moura J.F.,et al. Subcellular metal distributions and metallothionein associations in rough-toothed dolphins (Steno bredanensis) from Southeastern Brazil[J],2019,146.
APA	Monteiro F..,Lemos L.S..,de Moura J.F..,Rocha R.C.C..,Moreira I..,...&Hauser-Davis R.A..(2019).Subcellular metal distributions and metallothionein associations in rough-toothed dolphins (Steno bredanensis) from Southeastern Brazil.Marine Pollution Bulletin,146.
MLA	Monteiro F.,et al."Subcellular metal distributions and metallothionein associations in rough-toothed dolphins (Steno bredanensis) from Southeastern Brazil".Marine Pollution Bulletin 146(2019).