气候变化领域集成服务门户(CCPortal): Toxicological effects of graphene on mussel Mytilus galloprovincialis hemocytes after individual and combined exposure with triphenyl phosphate

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DOI	10.1016/j.marpolbul.2019.110838
	Toxicological effects of graphene on mussel Mytilus galloprovincialis hemocytes after individual and combined exposure with triphenyl phosphate
	Meng X.; Li F.; Wang X.; Liu J.; Ji C.; Wu H.
发表日期	2020
ISSN	0025326X
卷号	151
英文摘要	Graphene nanoparticles are increasingly released into the aquatic environment with the growth of production. However, there are rare investigations focusing on the interaction of nanoparticles with other contaminants. Triphenyl phosphate (TPP) is a frequently detected organophosphate flame retardant in the environment. This study aimed to assess the joint effects of graphene and TPP on Mytilus galloprovincialis hemocytes. Oxidative stress could be induced by graphene and TPP in mussel hemocytes, which could further cause apoptosis, DNA damage and decrease in the lysosomal membrane stability (LMS). Moreover, hemocytes could internalize graphene, thereby resulting in oxidative stress. The oxidative stress and DNA damage in hemocytes were increased in the graphene-exposed group, but significantly reduced after combined exposure of graphene and TPP. The up-regulated genes, including NF-κB, Bcl-2 and Ras, were mainly associated with reduced apoptosis and DNA damage after co-exposure to graphene and TPP. © 2020 Elsevier Ltd
英文关键词	Graphene; Hemocytes; Immunity; Joint effects; Triphenyl phosphate (TPP)
语种	英语
scopus关键词	Cell death; DNA; Molluscs; Nanoparticles; Oxidative stress; Hemocytes; Immunity; Joint effect; Lysosomal membrane stabilities; Mytilus galloprovincialis; Organophosphate flame retardants; Toxicological effects; Triphenyl phosphate; Graphene; catalase; DNA; flame retardant; glutathione; glutathione transferase; graphene; immunoglobulin enhancer binding protein; organophosphate; protein bcl 2; Ras protein; superoxide dismutase; triphenylphosphate; unclassified drug; graphite; organophosphate; triphenyl phosphate; apoptosis; DNA; flame retardant; immunity; membrane; nanoparticle; organophosphate; oxidative stress; adult; animal cell; animal experiment; antioxidant activity; apoptosis; Article; Bcl 2 gene; blood cell; cellular parameters; controlled study; cytotoxicity; DNA damage; ecotoxicology; environmental exposure; gene expression regulation; genetic association; hemolymph; internalization; lysosome membrane; membrane stability; micronucleus test; Mytilus galloprovincialis; NF kappaB gene; nonhuman; oncogene ras; oxidative stress; phagocytosis; real time polymerase chain reaction; upregulation; animal; blood cell; metabolism; Mytilus; physiology; toxicity; water pollutant; Mytilus galloprovincialis; Animals; Graphite; Hemocytes; Mytilus; Organophosphates; Water Pollutants, Chemical
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/149224
作者单位	CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Key Laboratory of Coastal Environmental Processes, YICCAS, Yantai, 264003, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, 266071, China
推荐引用方式 GB/T 7714	Meng X.,Li F.,Wang X.,et al. Toxicological effects of graphene on mussel Mytilus galloprovincialis hemocytes after individual and combined exposure with triphenyl phosphate[J],2020,151.
APA	Meng X.,Li F.,Wang X.,Liu J.,Ji C.,&Wu H..(2020).Toxicological effects of graphene on mussel Mytilus galloprovincialis hemocytes after individual and combined exposure with triphenyl phosphate.Marine Pollution Bulletin,151.
MLA	Meng X.,et al."Toxicological effects of graphene on mussel Mytilus galloprovincialis hemocytes after individual and combined exposure with triphenyl phosphate".Marine Pollution Bulletin 151(2020).