气候变化领域集成服务门户(CCPortal): Histological; enzymatic and chemical analyses of the potential effects of differently sized microplastic particles upon long-term ingestion in zebrafish (Danio rerio)

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DOI	10.1016/j.marpolbul.2020.111022
	Histological; enzymatic and chemical analyses of the potential effects of differently sized microplastic particles upon long-term ingestion in zebrafish (Danio rerio)
	Batel A.; Baumann L.; Carteny C.C.; Cormier B.; Keiter S.H.; Braunbeck T.
发表日期	2020
ISSN	0025326X
卷号	153
英文摘要	In microplastics (MPs) research, there is an urgent need to critically reconsider methodological approaches and results published, since public opinion and political decisions might be based on studies using debatable methods and reporting questionable results. For instance, recent studies claim that MPs induce intestinal damage and that relatively large MPs are transferred to, e.g., livers in fish. However, there is methodological criticism and considerable concern whether MP transfer to surrounding tissues is plausible. Likewise, there is an ongoing discussion in MP research if MPs act as vectors for adsorbed hazardous chemicals. In this study, effects of very small (4–6 μm) and very large (125–500 μm) benzo(a) pyrene (BaP)-spiked polyethylene (PE) particles administered via different uptake routes (food chain vs. direct uptake) were compared in a 21-day zebrafish (Danio rerio) feeding experiment. Particular care was taken to prevent cross-contamination of MPs during dissection and histological sample preparation. In contrast to numerous reports in literature describing similar approaches, independent of exposure route and MP size, no adverse effects could be detected. Likewise, no BaP accumulation could be documented, and MPs were exclusively seen in the lumen of the intestinal tract, which, however, did not induce any histopathological effects. Results indicate that in fish MPs are taken up, pass along the intestinal lumen and are excreted without any symptoms of adverse effects. © 2020 Elsevier Ltd
英文关键词	Benzo(a)pyrene; CYP1A induction; Histology; Microplastic; Pathology; Polyethylene; Trophic transfer
语种	英语
scopus关键词	Barium compounds; Contamination; Fish; Histology; Microplastic; Particle size analysis; Pathology; Polyethylenes; Pyrene; Social aspects; Benzo(a)pyrene; Cross contamination; CYP1A induction; Feeding experiments; Hazardous chemicals; Methodological approach; Microplastic particles; Trophic transfer; Chemical analysis; benzo[a]pyrene; cytochrome P450 1A; microplastic; polyethylene; plastic; chemical analysis; cyprinid; enzyme; experimental study; histology; ingestion rate; nanoparticle; pathology; plastic waste; trophic structure; adult; animal experiment; animal tissue; Artemia; Article; bioaccumulation; controlled study; enzyme activity; enzyme induction; female; food chain; histopathology; intestine; male; microplastic pollution; nonhuman; particle size; toxicokinetics; zebra fish; animal; water pollutant; zebra fish; Danio rerio; Animals; Benzo(a)pyrene; Microplastics; Plastics; Water Pollutants, Chemical; Zebrafish
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/149111
作者单位	University of Heidelberg, Aquatic Ecology and Toxicology, Center for Organismal Studies, Im Neuenheimer Feld 504, Heidelberg, D-69120, Germany; Systemic Physiological and Ecotoxicologal Research (SPHERE), Department of Biology, University of Antwerp, Groenenborgerlaan 171, Antwerp, B-2020, Belgium; Man-Technology-Environment Research Centre, School of Science and Technology, University of Örebro, Fakultetsgatan 1, Örebro, S-70182, Sweden; Univ. Bordeaux, EPOC UMR CNRS 5805, Allée Geoffroy Saint-Hilaire, Pessac Cedex, F-33615, France
推荐引用方式 GB/T 7714	Batel A.,Baumann L.,Carteny C.C.,et al. Histological; enzymatic and chemical analyses of the potential effects of differently sized microplastic particles upon long-term ingestion in zebrafish (Danio rerio)[J],2020,153.
APA	Batel A.,Baumann L.,Carteny C.C.,Cormier B.,Keiter S.H.,&Braunbeck T..(2020).Histological; enzymatic and chemical analyses of the potential effects of differently sized microplastic particles upon long-term ingestion in zebrafish (Danio rerio).Marine Pollution Bulletin,153.
MLA	Batel A.,et al."Histological; enzymatic and chemical analyses of the potential effects of differently sized microplastic particles upon long-term ingestion in zebrafish (Danio rerio)".Marine Pollution Bulletin 153(2020).