气候变化领域集成服务门户(CCPortal): Sunscreens containing zinc oxide nanoparticles can trigger oxidative stress and toxicity to the marine copepod Tigriopus japonicus

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DOI	10.1016/j.marpolbul.2020.111078
	Sunscreens containing zinc oxide nanoparticles can trigger oxidative stress and toxicity to the marine copepod Tigriopus japonicus
	Wong S.W.Y.; Zhou G.-J.; Leung P.T.Y.; Han J.; Lee J.-S.; Kwok K.W.H.; Leung K.M.Y.
发表日期	2020
ISSN	0025326X
卷号	154
英文摘要	The study, for the first time, evaluated the leaching rate of zinc oxide nanoparticles (nZnO) from human skins which were applied with three commercial sunscreens containing nZnO as an active ingredient. The leaching rate of nZnO varied greatly among the sunscreens, with a range of 8–72% (mean ± SD: 45% ± 33%). We further investigated their toxicities to the marine copepod Tigriopus japonicus. We found that 96-h median lethal concentrations of the three sunscreens to T. japonicus were > 5000, 230.6, and 43.0 mg chemical L−1, respectively, equivalent to Zn2+ concentrations at >82.5, 3.2, and 1.2 mg Zn L−1, respectively. Exposure to the individual sunscreens at environmentally realistic concentrations for 96 h led to up-regulation of antioxidant genes in T. japonicus, while they triggered the release of reactive oxygen species based on the results of in vivo assays. Evidently, these nZnO-included sunscreens can cause oxidative stress and hence pose risk to marine organisms. © 2020 Elsevier Ltd
英文关键词	Copepod; Ecotoxicology; Oxidative stress; Sunscreen; Zinc oxide nanoparticle
语种	英语
scopus关键词	II-VI semiconductors; Leaching; Marine biology; Nanoparticles; Oxidative stress; Toxicity; Zinc oxide; ZnO nanoparticles; Active ingredients; Copepod; Eco-toxicology; Leaching rates; Marine organisms; Median Lethal concentration; Up-regulation; Zinc oxide nanoparticles; Sun hoods; reactive oxygen metabolite; sunscreen; zinc oxide nanoparticle; nanoparticle; sunscreen; zinc oxide; antioxidant; concentration (composition); crustacean; ecotoxicology; nanoparticle; oxidative stress; oxide; reactive oxygen species; toxicity; zinc; adult; animal experiment; Article; concentration (parameter); controlled study; ecotoxicity; environmental exposure; female; gene expression; human; human experiment; in vivo study; leaching; male; nonhuman; oxidative stress; particle size; quantitative analysis; risk assessment; Tigriopus japonicus; toxicity testing; transmission electron microscopy; animal; copepod; drug effect; oxidative stress; pharmacology; water pollutant; Copepoda; Tigriopus japonicus; Animals; Copepoda; Nanoparticles; Oxidative Stress; Sunscreening Agents; Water Pollutants, Chemical; Zinc Oxide
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/149023
作者单位	The Swire Institute of Marine Science and School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong; State Key Laboratory of Marine Pollution, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong; Department of Biological Science, College of Science, Sungkyunkwan University, Suwon, South Korea; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
推荐引用方式 GB/T 7714	Wong S.W.Y.,Zhou G.-J.,Leung P.T.Y.,et al. Sunscreens containing zinc oxide nanoparticles can trigger oxidative stress and toxicity to the marine copepod Tigriopus japonicus[J],2020,154.
APA	Wong S.W.Y..,Zhou G.-J..,Leung P.T.Y..,Han J..,Lee J.-S..,...&Leung K.M.Y..(2020).Sunscreens containing zinc oxide nanoparticles can trigger oxidative stress and toxicity to the marine copepod Tigriopus japonicus.Marine Pollution Bulletin,154.
MLA	Wong S.W.Y.,et al."Sunscreens containing zinc oxide nanoparticles can trigger oxidative stress and toxicity to the marine copepod Tigriopus japonicus".Marine Pollution Bulletin 154(2020).