气候变化领域集成服务门户(CCPortal): Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma

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DOI	10.1016/j.marpolbul.2020.111349
	Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma
	Chen J.-C.; Chen M.-Y.; Fang C.; Zheng R.-H.; Jiang Y.-L.; Zhang Y.-S.; Wang K.-J.; Bailey C.; Segner H.; Bo J.
发表日期	2020
ISSN	0025326X
卷号	158
英文摘要	Microplastic (MP) pollution is an emerging contaminant in aquatic environments worldwide. Nonetheless, the developmental toxicity of MPs in the early life stages of fish and the mechanisms involved are not yet fully understood. The present study investigated the effects of different concentrations of polystyrene (PS) MPs on the early development of the marine model fish the medaka Oryzias melastigma. Our results showed that waterborne exposure to PS MPs significantly delayed the hatching time, altered the heartbeat and decreased the hatching rate of embryos. Furthermore, the genes involved in cardiac development, encoding for embryo-hatching enzymes, as well as inflammatory responses were significantly upregulated. The transcriptome results showed that mainly the pathways involved in metabolism, immune response, genetic information processing and diseases were significantly enriched. These results demonstrate that PS MPs negatively impact embryogenesis and the immune response of O. melastigma. © 2020 Elsevier Ltd
英文关键词	Cardiovascular toxicity; Hatching rate; Heart beats; Immunotoxicity; Inflammation
语种	英语
scopus关键词	Animal cell culture; Fish; Genes; Microplastic; Aquatic environments; Developmental toxicity; Early life stages of fishes; Emerging contaminant; Hatching enzymes; Inflammatory response; Oryzias melastigma; Waterborne exposure; Immune system; microplastic; polystyrene; transcriptome; plastic; cardiovascular system; concentration (composition); embryonic development; finfish; hatching; immune response; plastic waste; polymer; toxicity; animal experiment; animal tissue; Article; concentration (parameter); controlled study; developmental stage; developmental toxicity; embryo; embryo development; embryotoxicity; environmental disease; environmental impact; gene function; genetic parameters; hatching; heart beat; heart development; immune response; immunomodulation; immunotoxicity; marine species; metabolic parameters; microplastic pollution; nonhuman; Oryzias melastigma; time; upregulation; animal; embryo development; Oryzias; water pollutant; Oryzias melastigma; Oryziinae; Animals; Embryonic Development; Microplastics; Oryzias; Plastics; Water Pollutants, Chemical
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/148782
作者单位	Laboratory of Marine Biology and Ecology, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, 361102, China; State Key Laboratory of Marine Environmental Science, College of Ocean & Earth Sciences, Xiamen University, Xiamen, 361005, China; Fish Immunology and Pathology Laboratory, Animal Health Research Center (CISA-INIA), Madrid, Spain; Centre for Fish and Wildlife Health, Department of Infectious Diseases and Pathobiology, University of Bern, Bern, Switzerland
推荐引用方式 GB/T 7714	Chen J.-C.,Chen M.-Y.,Fang C.,et al. Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma[J],2020,158.
APA	Chen J.-C..,Chen M.-Y..,Fang C..,Zheng R.-H..,Jiang Y.-L..,...&Bo J..(2020).Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma.Marine Pollution Bulletin,158.
MLA	Chen J.-C.,et al."Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma".Marine Pollution Bulletin 158(2020).