气候变化领域集成服务门户(CCPortal): Detoxification roles of tributyltin-binding protein type 2 in Japanese medaka (Oryzias latipes) exposed to tributyltin

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DOI	10.1016/j.marpolbul.2020.111445
	Detoxification roles of tributyltin-binding protein type 2 in Japanese medaka (Oryzias latipes) exposed to tributyltin
	Qiu X.; Takamura T.; Enoki S.; Kato-Unoki Y.; Takai Y.; Nagano Y.; Kinoshita M.; Kitano T.; Shimasaki Y.; Oshima Y.
发表日期	2020
ISSN	0025326X
卷号	159
英文摘要	Tributyltin-binding protein type 2 (TBT-bp2), a homolog of α1-acid glycoprotein, may contribute to both accumulation and detoxification of TBT in fish. In this study, we conducted acute TBT exposure tests using both wide-type (WT) and TBT-bp2−/− (KO) strains of medaka and compared their responses in survival time and accumulation of TBT. Deficiency of TBT-bp2 significantly accelerated the time to death of medaka and decreased the LC50 of TBT, indicating that the KO-strain is more sensitive to TBT. No significant difference in the intrinsic TBT concentration in surviving fish was observed between the two strains. However, the intrinsic TBT concentration in dead KO-strain was significantly lower than that in WT-strain. These findings provide direct evidence, supporting the hypothesis that TBT-bp2 plays a critical role in the detoxification of TBT in fish. © 2020 Elsevier Ltd
英文关键词	Detoxification; Genome editing; Medaka; Tributyltin; Tributyltin-binding protein
语种	英语
scopus关键词	Detoxification; Fish; Insecticides; Proteins; Alpha-1-acid glycoprotein; Binding proteins; Exposed to; Exposure tests; Japanese medaka; Oryzias latipes; Survival time; Tributyltin; Strain; binding protein; tributyltin; tributyltin binding protein type 2; unclassified drug; carrier protein; organotin compound; tributyltin; bioaccumulation; concentration (composition); detoxification; fish; protein; survival; animal experiment; Article; bioaccumulation; concentration (parameter); controlled study; detoxification; environmental exposure; infant; LC50; mortality; nonhuman; Oryzias latipes; protein function; survival; survival time; animal; non insulin dependent diabetes mellitus; Oryzias; Oryzias latipes; Oryziinae; Animals; Carrier Proteins; Diabetes Mellitus, Type 2; Oryzias; Trialkyltin Compounds
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/148669
作者单位	Institute of Environmental Health and Ecological Security, Jiangsu University, Zhenjiang, Jiangsu 212013, China; Laboratory of Marine Environmental Science, Faculty of Agriculture, Kyushu University, Fukuoka, 819-0395, Japan; Chemicals Evaluation and Research Institute, 3-2-7, Miyanojin, Kurume-shi, Fukuoka, 839-0801, Japan; Center for Advanced Instrumental and Educational Supports, Faculty of Agriculture, Kyushu University, Fukuoka, 819-0395, Japan; Department of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, 606-8502, Japan; Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Kumamoto, 860-8555, Japan; Institute of Nature and Environmental Technology, Kanazawa University, Kakuma-machi, 920-1192, Japan
推荐引用方式 GB/T 7714	Qiu X.,Takamura T.,Enoki S.,et al. Detoxification roles of tributyltin-binding protein type 2 in Japanese medaka (Oryzias latipes) exposed to tributyltin[J],2020,159.
APA	Qiu X..,Takamura T..,Enoki S..,Kato-Unoki Y..,Takai Y..,...&Oshima Y..(2020).Detoxification roles of tributyltin-binding protein type 2 in Japanese medaka (Oryzias latipes) exposed to tributyltin.Marine Pollution Bulletin,159.
MLA	Qiu X.,et al."Detoxification roles of tributyltin-binding protein type 2 in Japanese medaka (Oryzias latipes) exposed to tributyltin".Marine Pollution Bulletin 159(2020).