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DOI	10.1016/j.marpolbul.2020.111635
	Spatial distribution of antibiotic and heavy metal resistance genes in the Black Sea
	Sabatino R.; Di Cesare A.; Dzhembekova N.; Fontaneto D.; Eckert E.M.; Corno G.; Moncheva S.; Bertoni R.; Callieri C.
发表日期	2020
ISSN	0025326X
卷号	160
英文摘要	Antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARB) are worldwide considered as emerging contaminants of large interest, and a primary threat to human health. It is becoming clear that the environment plays a central role in the transmission, spread, and evolution of antibiotic resistance. Although marine systems have been largely investigated, only a few studies have considered the presence of ARGs in meso- and bathypelagic waters. To date, no molecular based studies have yet been made to investigate the occurrence of ARGs in the Black Sea, the largest meromictic basin in the world, receiving water from a number of important European rivers and their residues of anthropogenic activities in permanently stratified mesopelagic water masses. In this study, we determined the presence and the abundance of five ARGs (blaCTXM, ermB, qnrS, sul2, tetA) and of the heavy metal resistance gene (HMRG) czcA, in different sampling sites in the eastern and western Black Sea, at several depths (up to 1000 m) and various distances from the shoreline. Three ARGs (blaCTXM, sul2, and tetA) and czcA were present in at least 43% of the analysed samples, whereas ermB and qnrS were never detected. In particular, sul2 abundances increased significantly in coastal location, whereas tetA increased with sampling depth. These findings point out the Black Sea as a source of ARGs and HMRGs distributed along the whole water column. © 2020 Elsevier Ltd
英文关键词	Antibiotic resistance; Deep sea; Heavy metal resistance; Marine water
语种	英语
scopus关键词	Genes; Health risks; Heavy metals; Anthropogenic activity; Antibiotic resistance; Antibiotic resistance genes; Antibiotic-resistant bacteria; Coastal locations; Emerging contaminant; Heavy metal resistance; Receiving waters; Antibiotics; antibiotic agent; sea water; angiotensin receptor antagonist; antiinfective agent; dipeptidyl carboxypeptidase inhibitor; heavy metal; antibiotic resistance; gene expression; heavy metal; human activity; marine pollution; molecular analysis; spatial distribution; antibiotic resistance; antibiotic resistance gene; Article; bacterial gene; Black Sea; blaCTXM gene; coastal waters; czcA gene; ermB gene; gene; gene identification; gene number; genetic screening; heavy metal resistance gene; human activities; nonhuman; qnrS gene; river ecosystem; sea pollution; sul2 gene; tetA gene; water sampling; bacterial gene; environmental monitoring; human; waste water; Black Sea; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Bacterial Agents; Black Sea; Environmental Monitoring; Genes, Bacterial; Humans; Metals, Heavy; Waste Water
来源期刊	Marine Pollution Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/148562
作者单位	Water Research Institute - National Research Council of Italy (CNR-IRSA), Molecular Ecology Group (MEG), Largo Tonolli 50, Verbania (VB), 28922, Italy; Institute for Oceanology Fridtjof Nansen, Bulgarian Academy of Sciences, First May Street 40, P.O. Box 152, Varna, 9000, Bulgaria
推荐引用方式 GB/T 7714	Sabatino R.,Di Cesare A.,Dzhembekova N.,et al. Spatial distribution of antibiotic and heavy metal resistance genes in the Black Sea[J],2020,160.
APA	Sabatino R..,Di Cesare A..,Dzhembekova N..,Fontaneto D..,Eckert E.M..,...&Callieri C..(2020).Spatial distribution of antibiotic and heavy metal resistance genes in the Black Sea.Marine Pollution Bulletin,160.
MLA	Sabatino R.,et al."Spatial distribution of antibiotic and heavy metal resistance genes in the Black Sea".Marine Pollution Bulletin 160(2020).