气候变化领域集成服务门户(CCPortal): Relationship between the molecular composition; visible light absorption; and health-related properties of smoldering woodsmoke aerosols

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DOI	10.5194/acp-20-539-2020
	Relationship between the molecular composition; visible light absorption; and health-related properties of smoldering woodsmoke aerosols
	Kam Chan L.; Nguyen K.Q.; Karim N.; Yang Y.; Rice R.H.; He G.; Denison M.S.; Nguyen T.B.
发表日期	2020
ISSN	1680-7316
起始页码	539
结束页码	559
卷号	20 期号:1
英文摘要	Organic aerosols generated from the smoldering combustion of wood critically impact air quality and health for billions of people worldwide; yet, the links between the chemical components and the optical or biological effects of woodsmoke aerosol (WSA) are still poorly understood. In this work, an untargeted analysis of the molecular composition of smoldering WSA, generated in a controlled environment from nine types of heartwood fuels (African mahogany, birch, cherry, maple, pine, poplar, red oak, redwood, and walnut), identified several hundred compounds using gas chromatography mass spectrometry (GCMS) and nano-electrospray high-resolution mass spectrometry (HRMS) with tandem multistage mass spectrometry (MSn). The effects of WSA on cell toxicity as well as gene expression dependent on the aryl hydrocarbon receptor (AhR) and estrogen receptor (ER) were characterized with cellular assays, and the visible mass absorption coefficients (MACvis) of WSA were measured with ultraviolet-visible spectroscopy. The WSAs studied in this work have significant levels of biological and toxicological activity, with exposure levels in both an outdoor and indoor environment similar to or greater than those of other toxicants. A correlation between the HRMS molecular composition and aerosol properties found that phenolic compounds from the oxidative decomposition of lignin are the main drivers of aerosol effects, while the cellulose decomposition products play a secondary role; e.g., levoglucosan is anticorrelated with multiple effects. Polycyclic aromatic hydrocarbons (PAHs) are not expected to form at the combustion temperature in this work, nor were they observed above the detection limit; thus, biological and optical properties of the smoldering WSA are not attributed to PAHs. Syringyl compounds tend to correlate with cell toxicity, while the more conjugated molecules (including several compounds assigned to dimers) have higher AhR activity and MACvis. The negative correlation between cell toxicity and AhR activity suggests that the toxicity of smoldering WSA to cells is not mediated by the AhR. Both mass-normalized biological outcomes have a statistically significant dependence on the degree of combustion of the wood. In addition, our observations support the fact that the visible light absorption of WSA is at least partially due to charge transfer effects in aerosols, as previously suggested. Finally, MACvis has no correlation with toxicity or receptor signaling, suggesting that key chromophores in this work are not biologically active on the endpoints tested. © 2020 Author(s).
语种	英语
scopus关键词	absorption; aerosol; aerosol composition; air quality; biomass burning; combustion; light effect; smoke; Acer; Juglans; Quercus rubra; Swietenia
来源期刊	Atmospheric Chemistry and Physics
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/141608
作者单位	Department of Environmental Toxicology, University of California Davis, Davis, CA 95616, United States; Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, Sacramento, CA, United States
推荐引用方式 GB/T 7714	Kam Chan L.,Nguyen K.Q.,Karim N.,et al. Relationship between the molecular composition; visible light absorption; and health-related properties of smoldering woodsmoke aerosols[J],2020,20(1).
APA	Kam Chan L..,Nguyen K.Q..,Karim N..,Yang Y..,Rice R.H..,...&Nguyen T.B..(2020).Relationship between the molecular composition; visible light absorption; and health-related properties of smoldering woodsmoke aerosols.Atmospheric Chemistry and Physics,20(1).
MLA	Kam Chan L.,et al."Relationship between the molecular composition; visible light absorption; and health-related properties of smoldering woodsmoke aerosols".Atmospheric Chemistry and Physics 20.1(2020).