气候变化领域集成服务门户(CCPortal): Dermal sheath contraction powers stem cell niche relocation during hair cycle regression

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DOI	10.1126/science.aax9131
	Dermal sheath contraction powers stem cell niche relocation during hair cycle regression
	Heitman N.; Sennett R.; Mok K.-W.; Saxena N.; Srivastava D.; Martino P.; Grisanti L.; Wang Z.; Ma'ayan A.; Rompolas P.; Rendl M.
发表日期	2020
ISSN	0036-8075
起始页码	161
结束页码	166
卷号	367 期号:6474
英文摘要	Tissue homeostasis requires the balance of growth by cell production and regression through cell loss. In the hair cycle, during follicle regression, the niche traverses the skin through an unknown mechanism to reach the stem cell reservoir and trigger new growth. Here, we identify the dermal sheath that lines the follicle as the key driver of tissue regression and niche relocation through the smooth muscle contractile machinery that generates centripetal constriction force. We reveal that the calcium-calmodulin-myosin light chain kinase pathway controls sheath contraction. When this pathway is blocked, sheath contraction is inhibited, impeding follicle regression and niche relocation. Thus, our study identifies the dermal sheath as smooth muscle that drives follicle regression for reuniting niche and stem cells in order to regenerate tissue structure during homeostasis. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	aggrecan calcium calmodulin myosin light chain kinase cell component enzyme enzyme activity growth hair homeostasis muscle skin animal cell animal tissue Article controlled study cutaneous parameters dermal sheath contraction hair cycle regression hair follicle hair root in vivo study mouse nonhuman priority journal protein expression skin fibroblast smooth muscle contractility stem cell niche animal dermis genetics human muscle contraction mutant mouse strain physiology regeneration smooth muscle stem cell niche Aggrecans Animals Dermis Hair Follicle Humans Mice Mice, Mutant Strains Muscle Contraction Muscle, Smooth Regeneration Stem Cell Niche
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133791
推荐引用方式 GB/T 7714	Heitman N.,Sennett R.,Mok K.-W.,et al. Dermal sheath contraction powers stem cell niche relocation during hair cycle regression[J]. Science,2020,367(6474).
APA	Heitman N..,Sennett R..,Mok K.-W..,Saxena N..,Srivastava D..,...&Rendl M..(2020).Dermal sheath contraction powers stem cell niche relocation during hair cycle regression.,367(6474).
MLA	Heitman N.,et al."Dermal sheath contraction powers stem cell niche relocation during hair cycle regression".367.6474(2020).