气候变化领域集成服务门户(CCPortal): Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. Elegans

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DOI	10.1126/science.aaz6896
	Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. Elegans
	Frakes A.E.; Metcalf M.G.; Tronnes S.U.; Bar-Ziv R.; Durieux J.; Gildea H.K.; Kandahari N.; Monshietehadi S.; Dillin A.
发表日期	2020
ISSN	0036-8075
起始页码	436
结束页码	440
卷号	367 期号:6476
英文摘要	The ability of the nervous system to sense cellular stress and coordinate protein homeostasis is essential for organismal health. Unfortunately, stress responses that mitigate disturbances in proteostasis, such as the unfolded protein response of the endoplasmic reticulum (UPRER), become defunct with age. In this work, we expressed the constitutively active UPRER transcription factor, XBP-1s, in a subset of astrocyte-like glia, which extended the life span in Caenorhabditis elegans. Glial XBP-1s initiated a robust cell nonautonomous activation of the UPRER in distal cells and rendered animals more resistant to protein aggregation and chronic ER stress. Mutants deficient in neuropeptide processing and secretion suppressed glial cell nonautonomous induction of the UPRER and life-span extension. Thus, astrocyte-like glial cells play a role in regulating organismal ER stress resistance and longevity. Copyright © 2020 The Authors.
关键词	neuropeptide transcription factor ATF-6 protein, C elegans Caenorhabditis elegans protein carrier protein neuropeptide protein aggregate transcription factor XBP-1 protein, C elegans cell component cell organelle homeostasis longevity nematode nervous system peptide protein secretion Article astrocyte Caenorhabditis elegans cell activation chronic stress controlled study endoplasmic reticulum stress glia cell lifespan nonhuman priority journal protein aggregation protein expression protein secretion signal transduction unfolded protein response animal endoplasmic reticulum stress genetics glia longevity mutation physiology signal transduction Animalia Caenorhabditis elegans Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Carrier Proteins Endoplasmic Reticulum Stress Longevity Mutation Neuroglia Neuropeptides Protein Aggregates Signal Transduction Transcription Factors
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133766
推荐引用方式 GB/T 7714	Frakes A.E.,Metcalf M.G.,Tronnes S.U.,et al. Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. Elegans[J]. Science,2020,367(6476).
APA	Frakes A.E..,Metcalf M.G..,Tronnes S.U..,Bar-Ziv R..,Durieux J..,...&Dillin A..(2020).Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. Elegans.,367(6476).
MLA	Frakes A.E.,et al."Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. Elegans".367.6476(2020).