气候变化领域集成服务门户(CCPortal): Catalyst-controlled doubly enantioconvergent coupling of racemic alkyl nucleophiles and electrophiles

CCPortal

DOI	10.1126/science.aaz3855
	Catalyst-controlled doubly enantioconvergent coupling of racemic alkyl nucleophiles and electrophiles
	Huo H.; Gorsline B.J.; Fu G.C.
发表日期	2020
ISSN	0036-8075
起始页码	559
结束页码	564
卷号	367 期号:6477
英文摘要	Stereochemical control in the construction of carbon-carbon bonds between an alkyl electrophile and an alkyl nucleophile is a persistent challenge in organic synthesis. Classical substitution reactions via SN1 and SN2 pathways are limited in their ability to generate carbon-carbon bonds (inadequate scope, due to side reactions such as rearrangements and eliminations) and to control stereochemistry when beginning with readily available racemic starting materials (racemic products). Here, we report a chiral nickel catalyst that couples racemic electrophiles (propargylic halides) with racemic nucleophiles (b-zincated amides) to form carbon-carbon bonds in doubly stereoconvergent processes, affording a single stereoisomer of the product from two stereochemical mixtures of reactants. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	alkyl group carbon electrophile halide nickel nucleophile catalysis catalyst chemical compound nickel Article catalyst chemical bond chirality organic chemistry priority journal stereochemistry stereoconvergence stereoisomerism
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133752
推荐引用方式 GB/T 7714	Huo H.,Gorsline B.J.,Fu G.C.. Catalyst-controlled doubly enantioconvergent coupling of racemic alkyl nucleophiles and electrophiles[J]. Science,2020,367(6477).
APA	Huo H.,Gorsline B.J.,&Fu G.C..(2020).Catalyst-controlled doubly enantioconvergent coupling of racemic alkyl nucleophiles and electrophiles.,367(6477).
MLA	Huo H.,et al."Catalyst-controlled doubly enantioconvergent coupling of racemic alkyl nucleophiles and electrophiles".367.6477(2020).