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| DOI | 10.1126/science.aay9847 |
| Mosquito heat seeking is driven by an ancestral cooling receptor | |
| Greppi C.; Laursen W.J.; Budelli G.; Chang E.C.; Daniels A.M.; van Giesen L.; Smidler A.L.; Catteruccia F.; Garrity P.A. | |
| 发表日期 | 2020 |
| ISSN | 0036-8075 |
| 起始页码 | 681 |
| 结束页码 | 684 |
| 卷号 | 367期号:6478 |
| 英文摘要 | Mosquitoes transmit pathogens that kill >700,000 people annually. These insects use body heat to locate and feed on warm-blooded hosts, but the molecular basis of such behavior is unknown. Here, we identify ionotropic receptor IR21a, a receptor conserved throughout insects, as a key mediator of heat seeking in the malaria vector Anopheles gambiae. Although Ir21a mediates heat avoidance in Drosophila, we find it drives heat seeking and heat-stimulated blood feeding in Anopheles. At a cellular level, Ir21a is essential for the detection of cooling, suggesting that during evolution mosquito heat seeking relied on cooling-mediated repulsion. Our data indicate that the evolution of blood feeding in Anopheles involves repurposing an ancestral thermoreceptor from non–blood-feeding Diptera. Copyright © 2020 The Authors. |
| 关键词 | ionotropic receptorionotropic receptor 21atransient receptor potential channel A1unclassified drugancestrycoolingdisease transmissiondisease vectorflyhemophagymalariamosquitoproteinadultAedes aegyptialleleanimal experimentanimal tissueAnopheles gambiaeArticlecontrolled studycoolingDrosophila melanogasterfemalegenome-wide association studyheat acclimatizationheat sensitivityhumanimmunohistochemistrymalemosquitomosquito vectornonhumanpriority journalprotein expressionprotein localizationsanguivoresignal noise ratiowarmingAnopheles gambiaeDipteraHexapoda |
| 语种 | 英语 |
| 来源机构 | Science |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133735 |
| 推荐引用方式 GB/T 7714 | Greppi C.,Laursen W.J.,Budelli G.,et al. Mosquito heat seeking is driven by an ancestral cooling receptor[J]. Science,2020,367(6478). |
| APA | Greppi C..,Laursen W.J..,Budelli G..,Chang E.C..,Daniels A.M..,...&Garrity P.A..(2020).Mosquito heat seeking is driven by an ancestral cooling receptor.,367(6478). |
| MLA | Greppi C.,et al."Mosquito heat seeking is driven by an ancestral cooling receptor".367.6478(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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