气候变化领域集成服务门户(CCPortal): Butyrophilin 2A1 is essential for phosphoantigen reactivity by gd T cells

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DOI	10.1126/science.aay5516
	Butyrophilin 2A1 is essential for phosphoantigen reactivity by gd T cells
	Rigau M.; Ostrouska S.; Fulford T.S.; Johnson D.N.; Woods K.; Ruan Z.; McWilliam H.E.G.; Hudson C.; Tutuka C.; Wheatley A.K.; Kent S.J.; Villadangos J.A.; Pal B.; Kurts C.; Simmonds J.; Pelzing M.; Nash A.D.; Hammet A.; Verhagen A.M.; Vairo G.; Maraskovsky E.; Panousis C.; Gherardin N.A.; Cebon J.; Godfrey D.I.; Behren A.; Uldrich A.P.
发表日期	2020
ISSN	0036-8075
卷号	367 期号:6478
英文摘要	Gamma delta (gd) T cells are essential to protective immunity. In humans, most gd T cells express Vg9Vd2+ T cell receptors (TCRs) that respond to phosphoantigens (pAgs) produced by cellular pathogens and overexpressed by cancers. However, the molecular targets recognized by these gdTCRs are unknown. Here, we identify butyrophilin 2A1 (BTN2A1) as a key ligand that binds to the Vg9+ TCR g chain. BTN2A1 associates with another butyrophilin, BTN3A1, and these act together to initiate responses to pAg. Furthermore, binding of a second ligand, possibly BTN3A1, to a separate TCR domain incorporating Vd2 is also required. This distinctive mode of Ag-dependent T cell activation advances our understanding of diseases involving pAg recognition and creates opportunities for the development of gd T cell–based immunotherapies. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	antigen butyrophilin butyrophilin 2A1 butyrophilin 3A1 phosphoantigen unclassified drug antigen cancer cell immune response protein antigen antibody reaction antigen recognition Article controlled study gamma delta T lymphocyte human human cell immunocompetent cell immunotherapy lymphocyte activation priority journal protein analysis protein binding protein domain protein interaction
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133731
推荐引用方式 GB/T 7714	Rigau M.,Ostrouska S.,Fulford T.S.,et al. Butyrophilin 2A1 is essential for phosphoantigen reactivity by gd T cells[J]. Science,2020,367(6478).
APA	Rigau M..,Ostrouska S..,Fulford T.S..,Johnson D.N..,Woods K..,...&Uldrich A.P..(2020).Butyrophilin 2A1 is essential for phosphoantigen reactivity by gd T cells.,367(6478).
MLA	Rigau M.,et al."Butyrophilin 2A1 is essential for phosphoantigen reactivity by gd T cells".367.6478(2020).