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DOI | 10.1126/science.aaz7381 |
Biocatalytic synthesis of planar chiral macrocycles | |
Gagnon C.; Godin É.; Minozzi C.; Sosoe J.; Pochet C.; Collins S.K. | |
发表日期 | 2020 |
ISSN | 0036-8075 |
起始页码 | 917 |
结束页码 | 921 |
卷号 | 367期号:6480 |
英文摘要 | Macrocycles can restrict the rotation of substituents through steric repulsions, locking in conformations that provide or enhance the activities of pharmaceuticals, agrochemicals, aroma chemicals, and materials. In many cases, the arrangement of substituents in the macrocycle imparts an element of planar chirality. The difficulty in predicting when planar chirality will arise, as well as the limited number of synthetic methods to impart selectivity, have led to planar chirality being regarded as an irritant. We report a strategy for enantio- and atroposelective biocatalytic synthesis of planar chiral macrocycles. The macrocycles can be formed with high enantioselectivity from simple building blocks and are decorated with functionality that allows one to further modify the macrocycles with diverse structural features. © 2020 American Association for the Advancement of Science. All rights reserved. |
关键词 | biochemical compositionbiochemistrycatalystenzymeenzyme activitymolecular analysisarticlebiocatalystchiralityenantioselectivitysynthesis |
语种 | 英语 |
来源机构 | Science |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133700 |
推荐引用方式 GB/T 7714 | Gagnon C.,Godin É.,Minozzi C.,et al. Biocatalytic synthesis of planar chiral macrocycles[J]. Science,2020,367(6480). |
APA | Gagnon C.,Godin É.,Minozzi C.,Sosoe J.,Pochet C.,&Collins S.K..(2020).Biocatalytic synthesis of planar chiral macrocycles.,367(6480). |
MLA | Gagnon C.,et al."Biocatalytic synthesis of planar chiral macrocycles".367.6480(2020). |
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