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DOI	10.1126/science.aba2419
	Aminoalkyl radicals as halogen-atom transfer agents for activation of alkyl and aryl halides
	Constantin T.; Zanini M.; Regni A.; Sheikh N.S.; Juliá F.; Leonori D.
发表日期	2020
ISSN	0036-8075
起始页码	1021
结束页码	1026
卷号	367 期号:6481
英文摘要	Organic halides are important building blocks in synthesis, but their use in (photo)redox chemistry is limited by their low reduction potentials. Halogen-atom transfer remains the most reliable approach to exploit these substrates in radical processes despite its requirement for hazardous reagents and initiators such as tributyltin hydride. In this study, we demonstrate that a-aminoalkyl radicals, easily accessible from simple amines, promote the homolytic activation of carbon-halogen bonds with a reactivity profile mirroring that of classical tin radicals. This strategy conveniently engages alkyl and aryl halides in a wide range of redox transformations to construct sp3-sp3, sp3-sp2, and sp2-sp2 carbon-carbon bonds under mild conditions with high chemoselectivity. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	alkyl halide aryl halide halide halogen unclassified drug chemistry halogen radical tributyltin alkylation amino acid transport Article atom transfer radical polymerization catalysis chemical analysis chemical bond chemical reaction chemical structure electron transport photolysis priority journal
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133668
推荐引用方式 GB/T 7714	Constantin T.,Zanini M.,Regni A.,et al. Aminoalkyl radicals as halogen-atom transfer agents for activation of alkyl and aryl halides[J]. Science,2020,367(6481).
APA	Constantin T.,Zanini M.,Regni A.,Sheikh N.S.,Juliá F.,&Leonori D..(2020).Aminoalkyl radicals as halogen-atom transfer agents for activation of alkyl and aryl halides.,367(6481).
MLA	Constantin T.,et al."Aminoalkyl radicals as halogen-atom transfer agents for activation of alkyl and aryl halides".367.6481(2020).