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| DOI | 10.1126/science.aaw4115 |
| ZGLP1 is a determinant for the oogenic fate in mice | |
| Nagaoka S.I.; Nakaki F.; Miyauchi H.; Nosaka Y.; Ohta H.; Yabuta Y.; Kurimoto K.; Hayashi K.; Nakamura T.; Yamamoto T.; Saitou M. | |
| 发表日期 | 2020 |
| ISSN | 10959203 |
| 卷号 | 367期号:6482 |
| 英文摘要 | Sex determination of germ cells is vital to creating the sexual dichotomy of germ cell development, thereby ensuring sexual reproduction. However, the underlying mechanisms remain unclear. Here, we show that ZGLP1, a conserved transcriptional regulator with GATA-like zinc fingers, determines the oogenic fate in mice. ZGLP1 acts downstream of bone morphogenetic protein, but not retinoic acid (RA), and is essential for the oogenic program and meiotic entry. ZGLP1 overexpression induces differentiation of in vitro primordial germ cell-like cells (PGCLCs) into fetal oocytes by activating the oogenic programs repressed by Polycomb activities, whereas RA signaling contributes to oogenic program maturation and PGC program repression. Our findings elucidate the mechanism for mammalian oogenic fate determination, providing a foundation for promoting in vitro gametogenesis and reproductive medicine. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. |
| 关键词 | bone morphogenetic proteinpolycomb group proteinretinoic acidsignal transducing adaptor proteinStra8 protein, mousetranscription factortranscriptomeanimalcytologyfemalefetusgene expression regulationgeneticsknockout mousemalemeiosismetabolismmouseoocyteoocyte developmentphysiologysex determination processsex differentiationsignal transductionAdaptor Proteins, Signal TransducingAnimalsBone Morphogenetic ProteinsFemaleFetusGene Expression Regulation, DevelopmentalMaleMeiosisMiceMice, KnockoutOocytesOogenesisPolycomb-Group ProteinsSex Determination ProcessesSex DifferentiationSignal TransductionTranscription FactorsTranscriptomeTretinoin |
| 语种 | 英语 |
| 来源机构 | Science (New York, N.Y.) |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133646 |
| 推荐引用方式 GB/T 7714 | Nagaoka S.I.,Nakaki F.,Miyauchi H.,et al. ZGLP1 is a determinant for the oogenic fate in mice[J]. Science (New York, N.Y.),2020,367(6482). |
| APA | Nagaoka S.I..,Nakaki F..,Miyauchi H..,Nosaka Y..,Ohta H..,...&Saitou M..(2020).ZGLP1 is a determinant for the oogenic fate in mice.,367(6482). |
| MLA | Nagaoka S.I.,et al."ZGLP1 is a determinant for the oogenic fate in mice".367.6482(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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