气候变化领域集成服务门户(CCPortal): Cerebrospinal fluid influx drives acute ischemic tissue swelling

CCPortal

DOI	10.1126/science.aax7171
	Cerebrospinal fluid influx drives acute ischemic tissue swelling
	Mestre H.; Du T.; Sweeney A.M.; Liu G.; Samson A.J.; Peng W.; Mortensen K.N.; Stæger F.F.; Bork P.A.R.; Bashford L.; Toro E.R.; Tithof J.; Kelley D.H.; Thomas J.H.; Hjorth P.G.; Martens E.A.; Mehta R.I.; Solis O.; Blinder P.; Kleinfeld D.; Hirase H.; Mori Y.; Nedergaard M.
发表日期	2020
ISSN	10959203
卷号	367 期号:6483
英文摘要	Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction, which in turn enlarged the perivascular spaces and doubled glymphatic inflow speeds. Thus, our understanding of poststroke edema needs to be revised, and these findings could provide a conceptual basis for development of alternative treatment strategies. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
关键词	aquaporin 5 animal brain edema C57BL mouse cerebrospinal fluid cerebrovascular accident complication diagnostic imaging male metabolism mouse nuclear magnetic resonance imaging pathophysiology vasoconstriction Animals Aquaporin 5 Brain Edema Glymphatic System Magnetic Resonance Imaging Male Mice Mice, Inbred C57BL Stroke Vasoconstriction
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133645
推荐引用方式 GB/T 7714	Mestre H.,Du T.,Sweeney A.M.,et al. Cerebrospinal fluid influx drives acute ischemic tissue swelling[J]. Science (New York, N.Y.),2020,367(6483).
APA	Mestre H..,Du T..,Sweeney A.M..,Liu G..,Samson A.J..,...&Nedergaard M..(2020).Cerebrospinal fluid influx drives acute ischemic tissue swelling.,367(6483).
MLA	Mestre H.,et al."Cerebrospinal fluid influx drives acute ischemic tissue swelling".367.6483(2020).