气候变化领域集成服务门户(CCPortal): Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling

CCPortal

DOI	10.1126/science.aax0902
	Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling
	Loganathan S.K.; Schleicher K.; Malik A.; Quevedo R.; Langille E.; Teng K.; Oh R.H.; Rathod B.; Tsai R.; Samavarchi-Tehrani P.; Pugh T.J.; Gingras A.-C.; Schramek D.
发表日期	2020
ISSN	10959203
起始页码	1264
结束页码	1269
卷号	367 期号:6483
英文摘要	In most human cancers, only a few genes are mutated at high frequencies; most are mutated at low frequencies. The functional consequences of these recurrent but infrequent "long tail" mutations are often unknown. We focused on 484 long tail genes in head and neck squamous cell carcinoma (HNSCC) and used in vivo CRISPR to screen for genes that, upon mutation, trigger tumor development in mice. Of the 15 tumor-suppressor genes identified, ADAM10 and AJUBA suppressed HNSCC in a haploinsufficient manner by promoting NOTCH receptor signaling. ADAM10 and AJUBA mutations or monoallelic loss occur in 28% of human HNSCC cases and are mutually exclusive with NOTCH receptor mutations. Our results show that oncogenic mutations in 67% of human HNSCC cases converge onto the NOTCH signaling pathway, making NOTCH inactivation a hallmark of HNSCC. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133634
推荐引用方式 GB/T 7714	Loganathan S.K.,Schleicher K.,Malik A.,et al. Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling[J]. Science (New York, N.Y.),2020,367(6483).
APA	Loganathan S.K..,Schleicher K..,Malik A..,Quevedo R..,Langille E..,...&Schramek D..(2020).Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling.,367(6483).
MLA	Loganathan S.K.,et al."Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling".367.6483(2020).