气候变化领域集成服务门户(CCPortal): Diverse functionalization of strong alkyl C

CCPortal

DOI	10.1126/science.aba6146
	Diverse functionalization of strong alkyl C–H bonds by undirected borylation
	Oeschger R.; Su B.; Yu I.; Ehinger C.; Romero E.; He S.; Hartwig J.
发表日期	2020
ISSN	0036-8075
起始页码	736
结束页码	741
卷号	368 期号:6492
英文摘要	The selective functionalization of strong, typically inert carbon-hydrogen (C–H) bonds in organic molecules is changing synthetic chemistry. However, the undirected functionalization of primary C–H bonds without competing functionalization of secondary C–H bonds is rare. The borylation of alkyl C–H bonds has occurred previously with this selectivity, but slow rates required the substrate to be the solvent or in large excess. We report an iridium catalyst ligated by 2-methylphenanthroline with activity that enables, with the substrate as limiting reagent, undirected borylation of primary C–H bonds and, when primary C–H bonds are absent or blocked, borylation of strong secondary C–H bonds. Reactions at the resulting carbon-boron bond show how these borylations can lead to the installation of a wide range of carbon-carbon and carbon-heteroatom bonds at previously inaccessible positions of organic molecules. Copyright © 2020 The Authors,
关键词	catalyst chemical bonding chemical reaction ligand molecular analysis
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133492
推荐引用方式 GB/T 7714	Oeschger R.,Su B.,Yu I.,等. Diverse functionalization of strong alkyl C–H bonds by undirected borylation[J]. Science,2020,368(6492).
APA	Oeschger R..,Su B..,Yu I..,Ehinger C..,Romero E..,...&Hartwig J..(2020).Diverse functionalization of strong alkyl C–H bonds by undirected borylation.,368(6492).
MLA	Oeschger R.,et al."Diverse functionalization of strong alkyl C–H bonds by undirected borylation".368.6492(2020).