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DOI | 10.1126/science.abb7271 |
Total synthesis of bryostatin 3 | |
Trost B.M.; Wang Y.; Buckl A.K.; Huang Z.; Nguyen M.H.; Kuzmina O. | |
发表日期 | 2020 |
ISSN | 0036-8075 |
起始页码 | 1007 |
结束页码 | 1011 |
卷号 | 368期号:6494 |
英文摘要 | Bryostatins are a family of 21 complex marine natural products with a wide range of potent biological activities. Among all the 21 bryostatins, bryostatin 3 is structurally the most complex. Whereas nine total syntheses of bryostatins have been achieved to date, bryostatin 3 has only been targeted once and required the highest number of steps to synthesize (43 steps in the longest linear sequence and 88 total steps). Here, we report a concise total synthesis of bryostatin 3 using 22 steps in the longest linear sequence and 31 total steps through a highly convergent synthetic plan by the use of highly atom-economical and chemoselective transformations in which alkynes played a major role in reducing step count. © 2020 American Association for the Advancement of Science. All rights reserved. |
关键词 | bioactivitymarine environmentproteinalkynebiological productbryostatinbryostatin 3macrolidechemistrysynthesisAlkynesBiological ProductsBryostatinsChemistry Techniques, SyntheticMacrolides |
语种 | 英语 |
来源机构 | Science |
文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133462 |
推荐引用方式 GB/T 7714 | Trost B.M.,Wang Y.,Buckl A.K.,et al. Total synthesis of bryostatin 3[J]. Science,2020,368(6494). |
APA | Trost B.M.,Wang Y.,Buckl A.K.,Huang Z.,Nguyen M.H.,&Kuzmina O..(2020).Total synthesis of bryostatin 3.,368(6494). |
MLA | Trost B.M.,et al."Total synthesis of bryostatin 3".368.6494(2020). |
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