气候变化领域集成服务门户(CCPortal): Restoring light sensitivity using tunable near-infrared sensors

CCPortal

DOI	10.1126/science.aaz5887
	Restoring light sensitivity using tunable near-infrared sensors
	Nelidova D.; Morikawa R.K.; Cowan C.S.; Raics Z.; Goldblum D.; Scholl H.P.N.; Szikra T.; Szabo A.; Hillier D.; Roska B.
发表日期	2020
ISSN	10959203
起始页码	1108
结束页码	1113
卷号	368 期号:6495
英文摘要	Enabling near-infrared light sensitivity in a blind human retina may supplement or restore visual function in patients with regional retinal degeneration. We induced near-infrared light sensitivity using gold nanorods bound to temperature-sensitive engineered transient receptor potential (TRP) channels. We expressed mammalian or snake TRP channels in light-insensitive retinal cones in a mouse model of retinal degeneration. Near-infrared stimulation increased activity in cones, ganglion cell layer neurons, and cortical neurons, and enabled mice to perform a learned light-driven behavior. We tuned responses to different wavelengths, by using nanorods of different lengths, and to different radiant powers, by using engineered channels with different temperature thresholds. We targeted TRP channels to human retinas, which allowed the postmortem activation of different cell types by near-infrared light. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133455
推荐引用方式 GB/T 7714	Nelidova D.,Morikawa R.K.,Cowan C.S.,et al. Restoring light sensitivity using tunable near-infrared sensors[J]. Science (New York, N.Y.),2020,368(6495).
APA	Nelidova D..,Morikawa R.K..,Cowan C.S..,Raics Z..,Goldblum D..,...&Roska B..(2020).Restoring light sensitivity using tunable near-infrared sensors.,368(6495).
MLA	Nelidova D.,et al."Restoring light sensitivity using tunable near-infrared sensors".368.6495(2020).