气候变化领域集成服务门户(CCPortal): PIRs mediate innate myeloid cell memory to nonself MHC molecules

CCPortal

DOI	10.1126/science.aax4040
	PIRs mediate innate myeloid cell memory to nonself MHC molecules
	Dai H.; Lan P.; Zhao D.; Abou-Daya K.; Liu W.; Chen W.; Friday A.J.; Williams A.L.; Sun T.; Chen J.; Chen W.; Mortin-Toth S.; Danska J.S.; Wiebe C.; Nickerson P.; Li T.; Mathews L.R.; Turnquist H.R.; Nicotra M.L.; Gingras S.; Takayama E.; Kubagawa H.; Shlomchik M.J.; Oberbarnscheidt M.H.; Li X.C.; Lakkis F.G.
发表日期	2020
ISSN	10959203
起始页码	1122
结束页码	1127
卷号	368 期号:6495
英文摘要	Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and attenuates kidney and heart allograft rejection. Thus, innate myeloid cells acquire alloantigen-specific memory that can be targeted to improve transplant outcomes. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133451
推荐引用方式 GB/T 7714	Dai H.,Lan P.,Zhao D.,et al. PIRs mediate innate myeloid cell memory to nonself MHC molecules[J]. Science (New York, N.Y.),2020,368(6495).
APA	Dai H..,Lan P..,Zhao D..,Abou-Daya K..,Liu W..,...&Lakkis F.G..(2020).PIRs mediate innate myeloid cell memory to nonself MHC molecules.,368(6495).
MLA	Dai H.,et al."PIRs mediate innate myeloid cell memory to nonself MHC molecules".368.6495(2020).