气候变化领域集成服务门户(CCPortal): NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility

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DOI	10.1126/science.aay5134
	NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility
	Kiyozumi D.; Noda T.; Yamaguchi R.; Tobita T.; Matsumura T.; Shimada K.; Kodani M.; Kohda T.; Fujihara Y.; Ozawa M.; Yu Z.; Miklossy G.; Bohren K.M.; Horie M.; Okabe M.; Matzuk M.M.; Ikawa M.
发表日期	2020
ISSN	10959203
起始页码	1132
结束页码	1135
卷号	368 期号:6495
英文摘要	The lumicrine system is a postulated signaling system in which testis-derived (upstream) secreted factors enter the male reproductive tract to regulate epididymal (downstream) pathways required for sperm maturation. Until now, no lumicrine factors have been identified. We demonstrate that a testicular germ-cell-secreted epidermal growth factor-like protein, neural epidermal growth factor-like-like 2 (NELL2), specifically binds to an orphan receptor tyrosine kinase, c-ros oncogene 1 (ROS1), and mediates the differentiation of the initial segment (IS) of the caput epididymis. Male mice in which Nell2 had been knocked out were infertile. The IS-specific secreted proteases, ovochymase 2 (OVCH2) and A disintegrin and metallopeptidase 28 (ADAM28), were expressed upon IS maturation, and OVCH2 was required for processing of the sperm surface protein ADAM3, which is required for sperm fertilizing ability. This work identifies a lumicrine system essential for testis-epididymis-spermatozoa (NELL2-ROS1-OVCH2-ADAM3) signaling and male fertility. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133445
推荐引用方式 GB/T 7714	Kiyozumi D.,Noda T.,Yamaguchi R.,et al. NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility[J]. Science (New York, N.Y.),2020,368(6495).
APA	Kiyozumi D..,Noda T..,Yamaguchi R..,Tobita T..,Matsumura T..,...&Ikawa M..(2020).NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility.,368(6495).
MLA	Kiyozumi D.,et al."NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility".368.6495(2020).