气候变化领域集成服务门户(CCPortal): Exploring whole-genome duplicate gene retention with complex genetic interaction analysis

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DOI	10.1126/science.aaz5667
	Exploring whole-genome duplicate gene retention with complex genetic interaction analysis
	Kuzmin E.; VanderSluis B.; Nguyen Ba A.N.; Wang W.; Koch E.N.; Usaj M.; Khmelinskii A.; Usaj M.M.; van Leeuwen J.; Kraus O.; Tresenrider A.; Pryszlak M.; Hu M.-C.; Varriano B.; Costanzo M.; Knop M.; Moses A.; Myers C.L.; Andrews B.J.; Boone C.
发表日期	2020
ISSN	10959203
卷号	368 期号:6498
英文摘要	Whole-genome duplication has played a central role in the genome evolution of many organisms, including the human genome. Most duplicated genes are eliminated, and factors that influence the retention of persisting duplicates remain poorly understood. We describe a systematic complex genetic interaction analysis with yeast paralogs derived from the whole-genome duplication event. Mapping of digenic interactions for a deletion mutant of each paralog, and of trigenic interactions for the double mutant, provides insight into their roles and a quantitative measure of their functional redundancy. Trigenic interaction analysis distinguishes two classes of paralogs: a more functionally divergent subset and another that retained more functional overlap. Gene feature analysis and modeling suggest that evolutionary trajectories of duplicated genes are dictated by combined functional and structural entanglement factors. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
关键词	article duplicate gene gene deletion gene interaction human nonhuman paralogy quantitative analysis structure activity relation yeast
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133391
推荐引用方式 GB/T 7714	Kuzmin E.,VanderSluis B.,Nguyen Ba A.N.,et al. Exploring whole-genome duplicate gene retention with complex genetic interaction analysis[J]. Science (New York, N.Y.),2020,368(6498).
APA	Kuzmin E..,VanderSluis B..,Nguyen Ba A.N..,Wang W..,Koch E.N..,...&Boone C..(2020).Exploring whole-genome duplicate gene retention with complex genetic interaction analysis.,368(6498).
MLA	Kuzmin E.,et al."Exploring whole-genome duplicate gene retention with complex genetic interaction analysis".368.6498(2020).