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| DOI | 10.1126/science.aba5443 |
| Number of HIV-1 founder variants is determined by the recency of the source partner infection | |
| Villabona-Arenas C.J.; Hall M.; Lythgoe K.A.; Gaffney S.G.; Regoes R.R.; Hué S.; Atkins K.E. | |
| 发表日期 | 2020 |
| ISSN | 10959203 |
| 起始页码 | 103 |
| 结束页码 | 108 |
| 卷号 | 369期号:6499 |
| 英文摘要 | During sexual transmission, the high genetic diversity of HIV-1 within an individual is frequently reduced to one founder variant that initiates infection. Understanding the drivers of this bottleneck is crucial to developing effective infection control strategies. Little is known about the importance of the source partner during this bottleneck. To test the hypothesis that the source partner affects the number of HIV founder variants, we developed a phylodynamic model calibrated using genetic and epidemiological data on all existing transmission pairs for whom the direction of transmission and the infection stage of the source partner are known. Our results suggest that acquiring infection from someone in the acute (early) stage of infection increases the risk of multiple-founder variant transmission compared with acquiring infection from someone in the chronic (later) stage of infection. This study provides the first direct test of source partner characteristics to explain the low frequency of multiple-founder strain infections. Copyright © 2020, American Association for the Advancement of Science. |
| 关键词 | classificationfounder effectgenetic variationgeneticshumanHuman immunodeficiency virus 1Human immunodeficiency virus infectionphylogenysexualityvirologyvirus loadFounder EffectGenetic VariationHIV InfectionsHIV-1HumansPhylogenySexual PartnersViral Load |
| 语种 | 英语 |
| 来源机构 | Science (New York, N.Y.) |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133379 |
| 推荐引用方式 GB/T 7714 | Villabona-Arenas C.J.,Hall M.,Lythgoe K.A.,et al. Number of HIV-1 founder variants is determined by the recency of the source partner infection[J]. Science (New York, N.Y.),2020,369(6499). |
| APA | Villabona-Arenas C.J..,Hall M..,Lythgoe K.A..,Gaffney S.G..,Regoes R.R..,...&Atkins K.E..(2020).Number of HIV-1 founder variants is determined by the recency of the source partner infection.,369(6499). |
| MLA | Villabona-Arenas C.J.,et al."Number of HIV-1 founder variants is determined by the recency of the source partner infection".369.6499(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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