气候变化领域集成服务门户(CCPortal): Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

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DOI	10.1126/science.aaw2622
	Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain
	Horowitz A.M.; Fan X.; Bieri G.; Smith L.K.; Sanchez-Diaz C.I.; Schroer A.B.; Gontier G.; Casaletto K.B.; Kramer J.H.; Williams K.E.; Villeda S.A.
发表日期	2020
ISSN	10959203
起始页码	167
结束页码	173
卷号	369 期号:6500
英文摘要	Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice. Plasma concentrations of glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (Gpld1), a GPI-degrading enzyme derived from liver, were found to increase after exercise and to correlate with improved cognitive function in aged mice, and concentrations of Gpld1 in blood were increased in active, healthy elderly humans. Increasing systemic concentrations of Gpld1 in aged mice ameliorated age-related regenerative and cognitive impairments by altering signaling cascades downstream of GPI-anchored substrate cleavage. We thus identify a liver-to-brain axis by which blood factors can transfer the benefits of exercise in old age. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
关键词	glycosylphosphatidylinositol glycosylphosphatidylinositol phospholipase D phospholipase D aging animal animal experiment blood brain circulation cognition cognitive defect enzymology liver metabolism mouse nervous system development pathophysiology physiology regeneration signal transduction vascularization Aging Animals Blood Circulation Brain Cognition Cognitive Dysfunction Glycosylphosphatidylinositols Liver Mice Neurogenesis Phospholipase D Physical Conditioning, Animal Regeneration Signal Transduction
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133354
推荐引用方式 GB/T 7714	Horowitz A.M.,Fan X.,Bieri G.,et al. Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain[J]. Science (New York, N.Y.),2020,369(6500).
APA	Horowitz A.M..,Fan X..,Bieri G..,Smith L.K..,Sanchez-Diaz C.I..,...&Villeda S.A..(2020).Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.,369(6500).
MLA	Horowitz A.M.,et al."Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain".369.6500(2020).