气候变化领域集成服务门户(CCPortal): Contact area-dependent cell communication and the morphological invariance of ascidian embryogenesis

CCPortal

DOI	10.1126/science.aar5663
	Contact area-dependent cell communication and the morphological invariance of ascidian embryogenesis
	Guignard L.; Fiúza U.-M.; Leggio B.; Laussu J.; Faure E.; Michelin G.; Biasuz K.; Hufnagel L.; Malandain G.; Godin C.; Lemaire P.
发表日期	2020
ISSN	10959203
卷号	369 期号:6500
英文摘要	Marine invertebrate ascidians display embryonic reproducibility: Their early embryonic cell lineages are considered invariant and are conserved between distantly related species, despite rapid genomic divergence. Here, we address the drivers of this reproducibility. We used light-sheet imaging and automated cell segmentation and tracking procedures to systematically quantify the behavior of individual cells every 2 minutes during Phallusia mammillata embryogenesis. Interindividual reproducibility was observed down to the area of individual cell contacts. We found tight links between the reproducibility of embryonic geometries and asymmetric cell divisions, controlled by differential sister cell inductions. We combined modeling and experimental manipulations to show that the area of contact between signaling and responding cells is a key determinant of cell communication. Our work establishes the geometric control of embryonic inductions as an alternative to classical morphogen gradients and suggests that the range of cell signaling sets the scale at which embryonic reproducibility is observed. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
关键词	animal cell communication cell division cell tracking cytology embryology reproduction Urochordata Animals Cell Communication Cell Division Cell Tracking Reproduction Urochordata
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133347
推荐引用方式 GB/T 7714	Guignard L.,Fiúza U.-M.,Leggio B.,et al. Contact area-dependent cell communication and the morphological invariance of ascidian embryogenesis[J]. Science (New York, N.Y.),2020,369(6500).
APA	Guignard L..,Fiúza U.-M..,Leggio B..,Laussu J..,Faure E..,...&Lemaire P..(2020).Contact area-dependent cell communication and the morphological invariance of ascidian embryogenesis.,369(6500).
MLA	Guignard L.,et al."Contact area-dependent cell communication and the morphological invariance of ascidian embryogenesis".369.6500(2020).