气候变化领域集成服务门户(CCPortal): Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression

CCPortal

DOI	10.1126/science.aay1813
	Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression
	Taniguchi S.; Elhance A.; Van Duzer A.; Kumar S.; Leitenberger J.J.; Oshimori N.
发表日期	2020
ISSN	10959203
卷号	369 期号:6501
英文摘要	Targeting the cross-talk between tumor-initiating cells (TICs) and the niche microenvironment is an attractive avenue for cancer therapy. We show here, using a mouse model of squamous cell carcinoma, that TICs play a crucial role in creating a niche microenvironment that is required for tumor progression and drug resistance. Antioxidant activity in TICs, mediated by the transcription factor NRF2, facilitates the release of a nuclear cytokine, interleukin-33 (IL-33). This cytokine promotes differentiation of macrophages that express the high-affinity immunoglobulin E receptor FcεRIα and are in close proximity to TICs. In turn, these IL-33-responding FcεRIα+ macrophages send paracrine transforming growth factor β (TGF-β) signals to TICs, inducing invasive and drug-resistant properties and further upregulating IL-33 expression. This TIC-driven, IL-33-TGF-β feedforward loop could potentially be exploited for cancer treatment. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133339
推荐引用方式 GB/T 7714	Taniguchi S.,Elhance A.,Van Duzer A.,et al. Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression[J]. Science (New York, N.Y.),2020,369(6501).
APA	Taniguchi S.,Elhance A.,Van Duzer A.,Kumar S.,Leitenberger J.J.,&Oshimori N..(2020).Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression.,369(6501).
MLA	Taniguchi S.,et al."Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression".369.6501(2020).