气候变化领域集成服务门户(CCPortal): Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition

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DOI	10.1126/science.aay9733
	Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition
	Chen J.W.; Rice T.A.; Bannock J.M.; Bielecka A.A.; Strauss J.D.; Catanzaro J.R.; Wang H.; Menard L.C.; Anolik J.H.; Palm N.W.; Meffre E.
发表日期	2020
ISSN	10959203
起始页码	320
结束页码	325
卷号	369 期号:6501
英文摘要	Restricted V(D)J recombination during fetal development was postulated to limit antibody repertoire breadth and prevent autoimmunity. However, newborn serum contains abundant autoantibodies, suggesting that B cell tolerance during gestation is not yet fully established. To investigate this apparent paradox, we evaluated the reactivities of more than 450 antibodies cloned from single B cells from human fetal liver, bone marrow, and spleen. We found that incomplete B cell tolerance in early human fetal life favored the accumulation of polyreactive B cells that bound both apoptotic cells and commensal bacteria from healthy adults. Thus, the restricted fetal preimmune repertoire contains potentially beneficial self-reactive innate-like B cell specificities that may facilitate the removal of apoptotic cells during development and shape gut microbiota assembly after birth. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
关键词	adult apoptosis article B lymphocyte cell specificity commensal efferocytosis fetus fetus liver human human cell human tissue intestine flora nonhuman spleen
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133317
推荐引用方式 GB/T 7714	Chen J.W.,Rice T.A.,Bannock J.M.,et al. Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition[J]. Science (New York, N.Y.),2020,369(6501).
APA	Chen J.W..,Rice T.A..,Bannock J.M..,Bielecka A.A..,Strauss J.D..,...&Meffre E..(2020).Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition.,369(6501).
MLA	Chen J.W.,et al."Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition".369.6501(2020).