气候变化领域集成服务门户(CCPortal): A brainwide atlas of synapses across the mouse life span

CCPortal

DOI	10.1126/science.aba3163
	A brainwide atlas of synapses across the mouse life span
	Cizeron M.; Qiu Z.; Koniaris B.; Gokhale R.; Komiyama N.H.; Fransén E.; Grant S.G.N.
发表日期	2020
ISSN	10959203
起始页码	270
结束页码	275
卷号	369 期号:6501
英文摘要	Synapses connect neurons together to form the circuits of the brain, and their molecular composition controls innate and learned behavior. We analyzed the molecular and morphological diversity of 5 billion excitatory synapses at single-synapse resolution across the mouse brain from birth to old age. A continuum of changes alters synapse composition in all brain regions across the life span. Expansion in synapse diversity produces differentiation of brain regions until early adulthood, and compositional changes cause dedifferentiation in old age. The spatiotemporal synaptome architecture of the brain potentially accounts for life-span transitions in intellectual ability, memory, and susceptibility to behavioral disorders. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
语种	英语
来源机构	Science (New York, N.Y.)
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133312
推荐引用方式 GB/T 7714	Cizeron M.,Qiu Z.,Koniaris B.,et al. A brainwide atlas of synapses across the mouse life span[J]. Science (New York, N.Y.),2020,369(6501).
APA	Cizeron M..,Qiu Z..,Koniaris B..,Gokhale R..,Komiyama N.H..,...&Grant S.G.N..(2020).A brainwide atlas of synapses across the mouse life span.,369(6501).
MLA	Cizeron M.,et al."A brainwide atlas of synapses across the mouse life span".369.6501(2020).