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| DOI | 10.1111/ele.13164 |
| Sexual dimorphism in immunity across animals: a meta-analysis | |
| Kelly C.D.; Stoehr A.M.; Nunn C.; Smyth K.N.; Prokop Z.M. | |
| 发表日期 | 2018 |
| ISSN | 1461023X |
| 卷号 | 21期号:12 |
| 英文摘要 | In animals, sex differences in immunity are proposed to shape variation in infection prevalence and intensity among individuals in a population, with females typically expected to exhibit superior immunity due to life-history trade-offs. We performed a systematic meta-analysis to investigate the magnitude and direction of sex differences in immunity and to identify factors that shape sex-biased immunocompetence. In addition to considering taxonomic and methodological effects as moderators, we assessed age-related effects, which are predicted to occur if sex differences in immunity are due to sex-specific resource allocation trade-offs with reproduction. In a meta-analysis of 584 effects from 124 studies, we found that females exhibit a significantly stronger immune response than do males, but the effect size is relatively small, and became non-significant after controlling for phylogeny. Female-biased immunity was more pronounced in adult than immature animals. More recently published studies did not report significantly smaller effect sizes. Among taxonomic and methodological subsets of the data, some of the largest effect sizes were in insects, further supporting previous suggestions that testosterone is not the only potential driver of sex differences in immunity. Our findings challenge the notion of pervasive biases towards female-biased immunity and the role of testosterone in driving these differences. © 2018 John Wiley & Sons Ltd/CNRS |
| 英文关键词 | Immune response; immunity; life-history; sexual dimorphism |
| 语种 | 英语 |
| scopus关键词 | immune response; immunity; immunocompetence; life history; meta-analysis; phylogeny; reproduction; resource allocation; sexual dimorphism; testosterone; trade-off; Animalia; Hexapoda; animal; female; immunity; infection; insect; male; meta analysis; phylogeny; reproduction; sexual characteristics; Animals; Female; Immunity; Infection; Insecta; Male; Phylogeny; Reproduction; Sex Characteristics |
| 来源期刊 | Ecology Letters
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/121212 |
| 作者单位 | Département des sciences biologiques, Université du Québec à Montréal, C.P. 8888, succursale Centre-Ville, Montreal, QC H3C 3P8, Canada; Department of Biological Sciences, Butler University, 4600 Sunset Avenue, Indianapolis, IN, United States; Department of Evolutionary Anthropology, Duke University, Science Drive, Durham, NC 27708, United States; Duke Global Health Institute, Duke University, Trent Drive, Durham, NC 27710, United States; University Program in Ecology, Nicholas School of the Environment, Duke University, Durham, NC 27708, United States; Institute of Environmental Sciences, Jagiellonian University, Gronostajowa 7, Krakow, 30–387, Poland |
| 推荐引用方式 GB/T 7714 | Kelly C.D.,Stoehr A.M.,Nunn C.,et al. Sexual dimorphism in immunity across animals: a meta-analysis[J],2018,21(12). |
| APA | Kelly C.D.,Stoehr A.M.,Nunn C.,Smyth K.N.,&Prokop Z.M..(2018).Sexual dimorphism in immunity across animals: a meta-analysis.Ecology Letters,21(12). |
| MLA | Kelly C.D.,et al."Sexual dimorphism in immunity across animals: a meta-analysis".Ecology Letters 21.12(2018). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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