气候变化领域集成服务门户(CCPortal): The impact of host genetic diversity on virus evolution and emergence

CCPortal

DOI	10.1111/ele.12890
	The impact of host genetic diversity on virus evolution and emergence
	Rodríguez-Nevado C.; Lam T.T.-Y.; Holmes E.C.; Pagán I.
发表日期	2019
ISSN	1461023X
卷号	21 期号:2
英文摘要	Accumulating evidence indicates that biodiversity has an important impact on parasite evolution and emergence. The vast majority of studies in this area have only considered the diversity of species within an environment as an overall measure of biodiversity, overlooking the role of genetic diversity within a particular host species. Although theoretical models propose that host genetic diversity in part shapes that of the infecting parasite population, and hence modulates the risk of parasite emergence, this effect has seldom been tested empirically. Using Rabies virus (RABV) as a model parasite, we provide evidence that greater host genetic diversity increases both parasite genetic diversity and the likelihood of a host being a donor in RABV cross-species transmission events. We conclude that host genetic diversity may be an important determinant of parasite evolution and emergence. © 2017 John Wiley & Sons Ltd/CNRS
英文关键词	Biodiversity; host genetic diversity; parasite emergence; rabies virus; virus evolution
语种	英语
scopus关键词	Rabies virus; animal; biodiversity; genetic variation; genetics; host range; parasite; Rabies virus; Animals; Biodiversity; Genetic Variation; Host Specificity; Parasites; Rabies virus
来源期刊	Ecology Letters
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/121168
作者单位	Centro de Biotecnología y Genómica de Plantas (Universidad Politécnica de Madrid – Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria), Madrid, 28223, Spain; State Key Laboratory of Emerging Infectious Diseases, Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia
推荐引用方式 GB/T 7714	Rodríguez-Nevado C.,Lam T.T.-Y.,Holmes E.C.,et al. The impact of host genetic diversity on virus evolution and emergence[J],2019,21(2).
APA	Rodríguez-Nevado C.,Lam T.T.-Y.,Holmes E.C.,&Pagán I..(2019).The impact of host genetic diversity on virus evolution and emergence.Ecology Letters,21(2).
MLA	Rodríguez-Nevado C.,et al."The impact of host genetic diversity on virus evolution and emergence".Ecology Letters 21.2(2019).