气候变化领域集成服务门户(CCPortal): Immunosenescence in wild animals: meta-analysis and outlook

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DOI	10.1111/ele.13343
	Immunosenescence in wild animals: meta-analysis and outlook
	Peters A.; Delhey K.; Nakagawa S.; Aulsebrook A.; Verhulst S.
发表日期	2019
ISSN	1461023X
卷号	22 期号:10
英文摘要	Immunosenescence, the decline in immune defense with age, is an important mortality source in elderly humans but little is known of immunosenescence in wild animals. We systematically reviewed and meta-analysed evidence for age-related changes in immunity in captive and free-living populations of wild species (321 effect sizes in 62 studies across 44 species of mammals, birds and reptiles). As in humans, senescence was more evident in adaptive (acquired) than innate immune functions. Declines were evident for cell function (antibody response), the relative abundance of naïve immune cells and an in vivo measure of overall immune responsiveness (local response to phytohaemagglutinin injection). Inflammatory markers increased with age, similar to chronic inflammation associated with human immunosenescence. Comparisons across taxa and captive vs free-living animals were difficult due to lack of overlap in parameters and species measured. Most studies are cross-sectional, which yields biased estimates of age-effects when immune function co-varies with survival. We therefore suggest longitudinal sampling approaches, and highlight techniques from human cohort studies that can be incorporated into ecological research. We also identify avenues to address predictions from evolutionary theory and the contribution of immunosenescence to age-related increases in disease susceptibility and mortality. © 2019 John Wiley & Sons Ltd/CNRS
英文关键词	Adaptive immunity; ageing; eco-immunology; gerontology; immune senescence; inflammaging; innate immunity; life-history trade-offs; PHA; senescence; wildlife diseases
语种	英语
scopus关键词	adaptive management; age-related difference; aging; captive population; cell; comparative study; elderly population; evolutionary theory; immune response; immunoassay; life history theory; meta-analysis; mortality; sampling; trade-off; wild population; Animalia; Aves; Mammalia; Reptilia; aging; animal; bird; cross-sectional study; immunosenescence; inflammation; mammal; meta analysis; physiology; reptile; Aging; Animals; Birds; Cross-Sectional Studies; Immunosenescence; Inflammation; Mammals; Reptiles
来源期刊	Ecology Letters
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/121044
作者单位	School of Biological Sciences, Monash University, Clayton, VIC 3800, Australia; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia; School of BioSciences, University of Melbourne, Parkville, VIC 3010, Australia; Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, 9747 AG, Netherlands
推荐引用方式 GB/T 7714	Peters A.,Delhey K.,Nakagawa S.,et al. Immunosenescence in wild animals: meta-analysis and outlook[J],2019,22(10).
APA	Peters A.,Delhey K.,Nakagawa S.,Aulsebrook A.,&Verhulst S..(2019).Immunosenescence in wild animals: meta-analysis and outlook.Ecology Letters,22(10).
MLA	Peters A.,et al."Immunosenescence in wild animals: meta-analysis and outlook".Ecology Letters 22.10(2019).