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DOI	10.1111/ele.12490
	Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens
	Vijendravarma R.K.; Narasimha S.; Chakrabarti S.; Babin A.; Kolly S.; Lemaitre B.; Kawecki T.J.
发表日期	2015
ISSN	1461-023X
EISSN	1461-0248
卷号	18 期号:10
英文摘要	The animal gut plays a central role in tackling two common ecological challenges, nutrient shortage and food-borne parasites, the former by efficient digestion and nutrient absorption, the latter by acting as an immune organ and a barrier. It remains unknown whether these functions can be independently optimised by evolution, or whether they interfere with each other. We report that Drosophila melanogaster populations adapted during 160 generations of experimental evolution to chronic larval malnutrition became more susceptible to intestinal infection with the opportunistic bacterial pathogen Pseudomonas entomophila. However, they do not show suppressed immune response or higher bacterial loads. Rather, their increased susceptibility to P. entomophila is largely mediated by an elevated predisposition to loss of intestinal barrier integrity upon infection. These results may reflect a trade-off between the efficiency of nutrient extraction from poor food and the protective function of the gut, in particular its tolerance to pathogen-induced damage. © 2015 John Wiley & Sons Ltd/CNRS.
英文关键词	Drosophila; Pseudomonas entomophila; Adaptation; Enteric infections; Experimental evolution; Host-parasite interactions; Innate immunity; Nutritional stress; Stress tolerance; Trade-offs
学科领域	adaptation; bacterium; experimental study; fly; gastroenteritis; host-parasite interaction; immune response; infectivity; innate behavior; malnutrition; nutritional disorder; nutritional requirement; physiological response; stress resistance; tolerance; trade-off; Animalia; Bacteria (microorganisms); Drosophila melanogaster; Pseudomonas entomophila; adaptation; animal; bacterial load; disease predisposition; Drosophila melanogaster; evolution; immunology; intestine; larva; malnutrition; microbiology; physiology; Pseudomonas; Adaptation, Physiological; Animals; Bacterial Load; Biological Evolution; Disease Susceptibility; Drosophila melanogaster; Intestines; Larva; Malnutrition; Pseudomonas
语种	英语
scopus关键词	adaptation; bacterium; experimental study; fly; gastroenteritis; host-parasite interaction; immune response; infectivity; innate behavior; malnutrition; nutritional disorder; nutritional requirement; physiological response; stress resistance; tolerance; trade-off; Animalia; Bacteria (microorganisms); Drosophila melanogaster; Pseudomonas entomophila; adaptation; animal; bacterial load; disease predisposition; Drosophila melanogaster; evolution; immunology; intestine; larva; malnutrition; microbiology; physiology; Pseudomonas; Adaptation, Physiological; Animals; Bacterial Load; Biological Evolution; Disease Susceptibility; Drosophila melanogaster; Intestines; Larva; Malnutrition; Pseudomonas
来源期刊	Ecology Letters
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/118634
作者单位	Department of Ecology and Evolution, University of Lausanne, Lausanne, CH 1015, Switzerland; Global Health Institute, EPFL, Lausanne, CH 1015, Switzerland; INRA, Université Nice Sophia Antipolis, CNRS, UMR 1355-7254 Institut Sophia Agrobiotech, France
推荐引用方式 GB/T 7714	Vijendravarma R.K.,Narasimha S.,Chakrabarti S.,et al. Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens[J],2015,18(10).
APA	Vijendravarma R.K..,Narasimha S..,Chakrabarti S..,Babin A..,Kolly S..,...&Kawecki T.J..(2015).Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens.Ecology Letters,18(10).
MLA	Vijendravarma R.K.,et al."Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens".Ecology Letters 18.10(2015).