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DOI	10.1111/ele.12639
	Facilitation through altered resource availability in a mixed-species rodent malaria infection
	Ramiro R.S.; Pollitt L.C.; Mideo N.; Reece S.E.
发表日期	2016
ISSN	1461-023X
EISSN	1461-0248
卷号	19 期号:9
英文摘要	A major challenge in disease ecology is to understand how co-infecting parasite species interact. We manipulate in vivo resources and immunity to explain interactions between two rodent malaria parasites, Plasmodium chabaudi and P. yoelii. These species have analogous resource-use strategies to the human parasites Plasmodium falciparum and P. vivax: P. chabaudi and P. falciparum infect red blood cells (RBC) of all ages (RBC generalist); P. yoelii and P. vivax preferentially infect young RBCs (RBC specialist). We find that: (1) recent infection with the RBC generalist facilitates the RBC specialist (P. yoelii density is enhanced ~10 fold). This occurs because the RBC generalist increases availability of the RBC specialist's preferred resource; (2) co-infections with the RBC generalist and RBC specialist are highly virulent; (3) and the presence of an RBC generalist in a host population can increase the prevalence of an RBC specialist. Thus, we show that resources shape how parasite species interact and have epidemiological consequences. © 2016 The Authors. Ecology Letters published by CNRS and John Wiley & Sons Ltd.
英文关键词	Co-infection; facilitation; genetically diverse infection; Malaria; Plasmodium chabaudi; Plasmodium yoelii; red blood cell; reticulocyte; species interactions; virulence
学科领域	animal; biological model; Coinfection; erythrocyte; genetics; host parasite interaction; malaria; male; mouse; parasitology; physiology; Plasmodium chabaudi; Plasmodium yoelii; prevalence; reproductive fitness; Rodent Diseases; veterinary; Animals; Coinfection; Erythrocytes; Genetic Fitness; Host-Parasite Interactions; Malaria; Male; Mice; Models, Biological; Plasmodium chabaudi; Plasmodium yoelii; Prevalence; Rodent Diseases; Plasmodium chabaudi; Plasmodium falciparum; Plasmodium yoelii; Rodentia
语种	英语
scopus关键词	animal; biological model; Coinfection; erythrocyte; genetics; host parasite interaction; malaria; male; mouse; parasitology; physiology; Plasmodium chabaudi; Plasmodium yoelii; prevalence; reproductive fitness; Rodent Diseases; veterinary; Animals; Coinfection; Erythrocytes; Genetic Fitness; Host-Parasite Interactions; Malaria; Male; Mice; Models, Biological; Plasmodium chabaudi; Plasmodium yoelii; Prevalence; Rodent Diseases; Plasmodium chabaudi; Plasmodium falciparum; Plasmodium yoelii; Rodentia
来源期刊	Ecology letters
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/118505
作者单位	Institutes of Evolutionary Biology, and Immunology and Infection Research, University of Edinburgh, Edinburgh, EH9 3JFL, UK, United Kingdom; Centre for Immunity, Infection & Evolution, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, Edinburgh, EH9 3JFL, UK; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Canada, Canada
推荐引用方式 GB/T 7714	Ramiro R.S.,Pollitt L.C.,Mideo N.,et al. Facilitation through altered resource availability in a mixed-species rodent malaria infection[J],2016,19(9).
APA	Ramiro R.S.,Pollitt L.C.,Mideo N.,&Reece S.E..(2016).Facilitation through altered resource availability in a mixed-species rodent malaria infection.Ecology letters,19(9).
MLA	Ramiro R.S.,et al."Facilitation through altered resource availability in a mixed-species rodent malaria infection".Ecology letters 19.9(2016).