气候变化领域集成服务门户(CCPortal): Joint associations of blood plasma proteins with overwinter survival of a large mammal

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DOI	10.1111/ele.12719
	Joint associations of blood plasma proteins with overwinter survival of a large mammal
	Garnier R.; Cheung C.K.; Watt K.A.; Pilkington J.G.; Pemberton J.M.; Graham A.L.
发表日期	2017
ISSN	1461-023X
EISSN	1461-0248
卷号	20 期号:2
英文摘要	In many wild animal populations, hosts are at risk of parasites and malnutrition and resource costs of defence may be difficult to afford. We postulate that proteins, important in homeostasis and immunity, play a complex but central role in condition dependence and resource costs of mammalian immune defence. To test this, we measured plasma concentrations of albumin, total proteins. Self-reactive antibodies and parasite-specific IgG in female Soay sheep. Using a principal component analysis, we found a new metric of condition reflecting individual variation in acquisition, assimilation and/or recycling of plasma proteins that predicted overwinter survival. Controlling for this metric, an age-dependent trade-off between antibody titres and protein reserves emerged, indicating costs of mounting an antibody response: younger individuals survived best when prioritising immunity while older individuals fared better when maintaining high-protein nutritional plane. These findings suggest fascinating roles for protein acquisition and allocation in influencing survival in wild animal populations. © 2017 John Wiley & Sons Ltd/CNRS
英文关键词	Disease ecology; ecological immunology; nutritional ecology; Ovis aries
学科领域	Animalia; Mammalia; Ovis aries; albuminoid; immunoglobulin G; plasma protein; animal; blood; domestic sheep; female; longevity; metabolism; physiology; season; Albumins; Animals; Blood Proteins; Female; Immunoglobulin G; Longevity; Seasons; Sheep, Domestic
语种	英语
scopus关键词	Animalia; Mammalia; Ovis aries; albuminoid; immunoglobulin G; plasma protein; animal; blood; domestic sheep; female; longevity; metabolism; physiology; season; Albumins; Animals; Blood Proteins; Female; Immunoglobulin G; Longevity; Seasons; Sheep, Domestic
来源期刊	Ecology Letters
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/118430
作者单位	Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, United States; Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
推荐引用方式 GB/T 7714	Garnier R.,Cheung C.K.,Watt K.A.,et al. Joint associations of blood plasma proteins with overwinter survival of a large mammal[J],2017,20(2).
APA	Garnier R.,Cheung C.K.,Watt K.A.,Pilkington J.G.,Pemberton J.M.,&Graham A.L..(2017).Joint associations of blood plasma proteins with overwinter survival of a large mammal.Ecology Letters,20(2).
MLA	Garnier R.,et al."Joint associations of blood plasma proteins with overwinter survival of a large mammal".Ecology Letters 20.2(2017).