气候变化领域集成服务门户(CCPortal): Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma

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DOI	10.1038/s41588-019-0436-5
	Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma
	Xu, Miao; Yao, Youyuan; Chen, Hui; Zhang, Shanshan; Cao, Su-Mei; Zhang, Zhe; Luo, Bing; Liu, Zhiwei; Li, Zilin; Xiang, Tong; He, Guiping; Feng, Qi-Sheng; Chen, Li-Zhen; Guo, Xiang; Jia, Wei-Hua; Chen, Ming-Yuan; Zhang, Xiao; Xie, Shang-Hang; Peng, Roujun; Chang, Ellen T.; Pedergnana, Vincent; Feng, Lin; Bei, Jin-Xin; Xu, Rui-Hua; Zeng, Mu-Sheng; Ye, Weimin; Adami, Hans-Olov; Lin, Xihong; Zhai, Weiwei; Zeng, Yi-Xin; Liu, Jianjun
发表日期	2019
ISSN	1061-4036
EISSN	1546-1718
卷号	51 期号:7
英文摘要	Epstein-Barr virus (EBV) infection is ubiquitous worldwide and is associated with multiple cancers, including nasopharyngeal carcinoma (NPC). The importance of EBV viral genomic variation in NPC development and its striking epidemic in southern China has been poorly explored. Through large-scale genome sequencing of 270 EBV isolates and two-stage association study of EBV isolates from China, we identify two non-synonymous EBV variants within BALF2 that are strongly associated with the risk of NPC (odds ratio (OR) = 8.69, P = 9.69 x 10(-25) for SNP 162476_C; OR = 6.14, P= 2.40 x 10(-32) for SNP 163364_T). The cumulative effects of these variants contribute to 83% of the overall risk of NPC in southern China. Phylogenetic analysis of the risk variants reveals a unique origin in Asia, followed by clonal expansion in NPC-endemic regions. Our results provide novel insights into the NPC endemic in southern China and also enable the identification of high-risk individuals for NPC prevention.
学科领域	Genetics & Heredity
语种	英语
WOS研究方向	Genetics & Heredity
来源期刊	NATURE GENETICS
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/112078
作者单位	Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med,Guangdong Key Lab, Guangzhou, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Xu, Miao,Yao, Youyuan,Chen, Hui,et al. Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma[J]. 中国科学院西北生态环境资源研究院,2019,51(7).
APA	Xu, Miao.,Yao, Youyuan.,Chen, Hui.,Zhang, Shanshan.,Cao, Su-Mei.,...&Liu, Jianjun.(2019).Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma.NATURE GENETICS,51(7).
MLA	Xu, Miao,et al."Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma".NATURE GENETICS 51.7(2019).