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DOI	10.1016/j.yebeh.2010.12.006
	Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator
	Zhao, Rong; Weng, Chun-Chun; Feng, Qi; Chen, Lulan; Zhang, Xu-Ying; Zhu, Hong-Yan; Wang, Yun; Ji, Yong-Hua
发表日期	2011
ISSN	1525-5050
EISSN	1525-5069
卷号	20 期号:2
英文摘要	The anticonvulsant activity of BmK AS, a sodium channel site 4-selective modulator purified from scorpion venom (Buthus martensi Karsch), was investigated in unanesthetized rats with acute pentylenetetrazole (PTZ)- and pilocarpine-induced seizures. Rats were microinjected in the CA1 region with either saline or BmK AS, followed by epileptogenic doses of PTZ or pilocarpine 30 minutes later. The anticonvulsant efficacy of BmK AS in PTZ- or pilocarpine-evoked seizure-like behavior and cortical epileptiform EEG activity was assessed. Intrahippocampal injections of BmK AS (0.05-1 mu g in 1 mu L) produced dose-dependent anticonvulsant activity in the PTZ model, suppressing seizure-associated behavior and reducing both the number and duration of high-amplitude, high-frequency discharges (HAFDs) on the EEG. In contrast, BmK AS did not affect the epileptiform EEG in the pilocarpine model over the same dose range, although it did increase the latency to status epilepticus onset and slightly, but significantly, reduced the seizure score. In summary, our results demonstrate that the sodium channel site 4-selective modulator BmK AS is an effective inhibitor of PTZ- but not pilocarpine-induced acute seizures. These results indicate that BmK AS may serve as a novel probe in exploring the role of different sodium channel subtypes in an epileptogenic setting and as a potential lead in developing antiepileptic drugs specifically for the therapy of sodium channel site 4-related epilepsy. (C) 2010 Elsevier Inc. All rights reserved.
关键词	BmK AS Sodium channels Epilepsy Pentylenetetrazole Pilocarpine Scorpion neurotoxin
学科领域	Behavioral Sciences; Neurosciences & Neurology; Psychiatry
语种	英语
WOS研究方向	Behavioral Sciences ; Clinical Neurology ; Psychiatry
来源期刊	EPILEPSY & BEHAVIOR
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/111640
作者单位	Shanghai Univ, Lab Neuropharmacol & Neurotoxicol, Shanghai 200444, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Rong,Weng, Chun-Chun,Feng, Qi,et al. Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator[J]. 中国科学院西北生态环境资源研究院,2011,20(2).
APA	Zhao, Rong.,Weng, Chun-Chun.,Feng, Qi.,Chen, Lulan.,Zhang, Xu-Ying.,...&Ji, Yong-Hua.(2011).Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator.EPILEPSY & BEHAVIOR,20(2).
MLA	Zhao, Rong,et al."Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator".EPILEPSY & BEHAVIOR 20.2(2011).