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DOI	10.1007/s10886-010-9783-5
	Regulation of Cell Division and Growth in Roots of Lactuca sativa L. Seedlings by the Ent-Kaurene Diterpenoid Rabdosin B
	Ding, Lan; Jing, Hongwei; Qin, Bo; Qi, Linlin; Li, Jing; Wang, Tao; Liu, Guoan
发表日期	2010
ISSN	0098-0331
EISSN	1573-1561
卷号	36 期号:5
英文摘要	Rabdosin B, an ent-kaurene diterpenoid purified from the air-dried aerial parts of Isodon japonica (Burm.f) Hara var. galaucocalyx (maxin) Hara, showed a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in lettuce seedlings (Lactuca sativa L.). Lower concentrations of rabdosin B (20-80 mu M) significantly promoted root growth, but its higher levels at 120-200 mu M, by contrast, had inhibitory effects. Additionally, all tested concentrations (10-40 mu M) inhibited root hair development of seedlings in a dose-dependent manner. Further investigations on the underlying mechanism revealed that the promotion effect of rabdosin B at the lower concentrations resulted from increasing the cell length in the mature region and enhancing the mitotic activity of meristematic cells in seedlings' root tips. In contrast, rabdosin B at higher concentrations inhibited root growth by affecting both cell length in the mature region and division of meristematic cells. Comet assay and cell cycle analysis demonstrated that the decrease of mitotic activity of root meristematic cells was due to DNA damage induced cell cycle retardation of the G(2) phase and S phase at different times.
关键词	Ent-kaurene diterpenoid Lactuca sativa L.Root growth Cell cycle arrest DNA damage Root hair
学科领域	Biochemistry & Molecular Biology; Environmental Sciences & Ecology
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Ecology
来源期刊	JOURNAL OF CHEMICAL ECOLOGY
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/111592
作者单位	NW Normal Univ, Coll Life Sci, Lanzhou 730070, Peoples R China
推荐引用方式 GB/T 7714	Ding, Lan,Jing, Hongwei,Qin, Bo,et al. Regulation of Cell Division and Growth in Roots of Lactuca sativa L. Seedlings by the Ent-Kaurene Diterpenoid Rabdosin B[J]. 中国科学院西北生态环境资源研究院,2010,36(5).
APA	Ding, Lan.,Jing, Hongwei.,Qin, Bo.,Qi, Linlin.,Li, Jing.,...&Liu, Guoan.(2010).Regulation of Cell Division and Growth in Roots of Lactuca sativa L. Seedlings by the Ent-Kaurene Diterpenoid Rabdosin B.JOURNAL OF CHEMICAL ECOLOGY,36(5).
MLA	Ding, Lan,et al."Regulation of Cell Division and Growth in Roots of Lactuca sativa L. Seedlings by the Ent-Kaurene Diterpenoid Rabdosin B".JOURNAL OF CHEMICAL ECOLOGY 36.5(2010).