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Even now, contemplation of an exhaustive roadmap to consider all aspects of well-management and efficient-conversion of MSW to sustainable energy in the 21st century has remained a central issue. Whereas, its generalizability in term of soil and underground water contamination, air pollution, and combating global warming is renowned a complex and problematic endeavor. The study presents a critical exposition in terms of efficiency (technical, technological, and ecological), sustainability pillars, and recent world-wide management practices to establish a new paradigm for MSW to energy. A primary objective of this study is to identify influencing factors and set forth viable indicators and metrics in term of MSW from different standpoints hiring innovative tangible and non-tangible tools and techniques. An inclusive strategy and model in term of an exhaustive paradigm is demonstrated with a real world application with some significant implications for future practice as a multilateral planning and design reference for students, researchers, scholars, and practitioners in the context of MSW to energy. This is the first ever effort that designed a novel-integrated paradigm framework for MSW to energy within multidisciplinary-oriented approaches of engineering, management, business, and social. Therefore, this study demonstrates important implications for real-world application in a synergistic manner as a multilateral design and implementation references for students, researchers, scholars, and practitioners in the related field. (C) 2019 Elsevier Ltd. All rights reserved.