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Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者:  Zhou Z.;  Torres M.;  Sha H.;  Halbrook C.J.;  van den Bergh F.;  Reinert R.B.;  Yamada T.;  Wang S.;  Luo Y.;  Hunter A.H.;  Wang C.;  Sanderson T.H.;  Liu M.;  Taylor A.;  Sesaki H.;  Lyssiotis C.A.;  Wu J.;  Kersten S.;  Beard D.A.;  Qi L.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/28
Hrd1 protein  membrane protein  Sel1L protein  sigma opiate receptor  sigma receptor 1  ubiquitin protein ligase E3  unclassified drug  biodegradation  cell organelle  membrane  mitochondrion  physiology  protein  turnover  animal cell  Article  brown adipocyte  cell contact  controlled study  endoplasmic reticulum  endoplasmic reticulum associated degradation  megamitochondria  mitochondrial dynamics  mitochondrion  mouse  nonhuman  priority journal  protein metabolism  protein protein interaction  thermogenesis  three-dimensional imaging  Mus  
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Gilan O.;  Rioja I.;  Knezevic K.;  Bell M.J.;  Yeung M.M.;  Harker N.R.;  Lam E.Y.N.;  Chung C.;  Bamborough P.;  Petretich M.;  Urh M.;  Atkinson S.J.;  Bassil A.K.;  Roberts E.J.;  Vassiliadis D.;  Burr M.L.;  Preston A.G.S.;  Wellaway C.;  Werner T.;  Gray J.R.;  Michon A.-M.;  Gobbetti T.;  Kumar V.;  Soden P.E.;  Haynes A.;  Vappiani J.;  Tough D.F.;  Taylor S.;  Dawson S.-J.;  Bantscheff M.;  Lindon M.;  Drewes G.;  Demont E.H.;  Daniels D.L.;  Grandi P.;  Prinjha R.K.;  Dawson M.A.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one  apremilast  bromodomain and extraterminal domain protein 1  bromodomain and extraterminal domain protein 2  bromodomain inhibitor  gsk 046  gsk 620  gsk 778  transcription factor  unclassified drug  cancer  drug  gene expression  immune response  inhibitor  physiological response  acute myeloid leukemia  animal experiment  animal model  animal tissue  antibody response  antineoplastic activity  antiproliferative activity  apoptosis  Article  binding affinity  controlled study  crystal structure  drug design  drug efficacy  drug protein binding  drug selectivity  drug specificity  drug structure  drug targeting  gene expression  high throughput screening  human  human cell  IC50  immunomodulation  in vivo study  inflammation  K-562 cell line  malignant neoplasm  MDA-MB-453 cell line  MOLM-13 cell line  mouse  nonhuman  priority journal  psoriasis