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Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Krawczyk K.;  Xue S.;  Buchmann P.;  Charpin-El-Hamri G.;  Saxena P.;  Hussherr M.-D.;  Shao J.;  Ye H.;  Xie M.;  Fussenegger M.
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/28
cell  diabetes  hormone  peptide  real time  rodent  Mus  calcium channel L type  inwardly rectifying potassium channel  inwardly rectifying potassium channel subunit Kir2.1  L-type calcium channel alpha(1C)  animal  calcium signaling  cell engineering  devices  electrostimulation  experimental diabetes mellitus  genetic transcription  genetics  HEK293 cell line  human  insulin dependent diabetes mellitus  insulin release  male  metabolism  mouse  pancreas islet beta cell  prostheses and orthoses  transgene  wireless communication  Animals  Bionics  Calcium Channels, L-Type  Calcium Signaling  Cell Engineering  Diabetes Mellitus, Experimental  Diabetes Mellitus, Type 1  Electric Stimulation  HEK293 Cells  Humans  Insulin Secretion  Insulin-Secreting Cells  Male  Mice  Potassium Channels, Inwardly Rectifying  Prostheses and Implants  Transcription, Genetic  Transgenes  Wireless Technology  
Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Yu J.;  Gimenez L.E.;  Hernandez C.C.;  Wu Y.;  Wein A.H.;  Han G.W.;  McClary K.;  Mittal S.R.;  Burdsall K.;  Stauch B.;  Wu L.;  Stevens S.N.;  Peisley A.;  Williams S.Y.;  Chen V.;  Millhauser G.L.;  Zhao S.;  Cone R.D.;  Stevens R.C.
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alpha intermedin  calcium ion  cyclic AMP  G protein coupled receptor  heterotrimeric guanine nucleotide binding protein  inwardly rectifying potassium channel  inwardly rectifying potassium channel subunit Kir7.1  melanocortin 4 receptor  n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]  unclassified drug  calcium  G protein coupled receptor  intermedin  inwardly rectifying potassium channel  Kir7.1 channel  ligand  melanocortin 4 receptor  n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]  protein binding  calcium  chemical binding  homeostasis  hormone  ligand  obesity  peptide  protein  Article  binding affinity  complex formation  crystallization  drug structure  extracellular calcium  human  ligand binding  priority journal  protein structure  receptor blocking  signal transduction  chemistry  genetics  mutation  protein multimerization  protein secondary structure  X ray crystallography  Calcium  Crystallography, X-Ray  Cyclic AMP  Humans  Ligands  Melanocyte-Stimulating Hormones  Mutation  Potassium Channels, Inwardly Rectifying  Protein Binding  Protein Multimerization  Protein Structure, Secondary  Receptor, Melanocortin, Type 4  Receptors, G-Protein-Coupled  Signal Transduction