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DOI	10.1126/science.aah4563
	A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection
	Emami S.N.; Lindberg B.G.; Hua S.; Hill S.R.; Mozuraitis R.; Lehmann P.; Birgersson G.; Borg-Karlson A.-K.; Ignell R.; Faye I.
发表日期	2017
ISSN	0036-8075
起始页码	1076
结束页码	1080
卷号	355 期号:6329
英文摘要	Malaria infection renders humans more attractive to Anopheles gambiae sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. We found that an isoprenoid precursor produced by Plasmodium falciparum, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects A. gambiae s.l. blood meal seeking and feeding behaviors as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO2, aldehydes, and monoterpenes, which together enhance vector attraction and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity; in a P. falciparum-infected blood meal, sporogony is increased. © 2017, American Association for the Advancement of Science. All rights reserved.
英文关键词	4 hydroxy 3 methyl but 2 enyl pyrophosphate; aldehyde; carbon dioxide; pyrophosphoric acid derivative; RNA; synaptobrevin; synaptotagmin I; terpene; unclassified drug; 4-hydroxy-3-methyl-2-butenyl diphosphate; organophosphate; blood; cells and cell components; disease vector; gene expression; hemophagy; infectivity; isoprenoid; malaria; metabolite; mosquito; pathogen; public health; survival; Anopheles gambiae; Article; body size; controlled study; down regulation; erythrocyte; feeding behavior; genetic transcription; homeostasis; infection sensitivity; malaria; mass fragmentography; nonhuman; parasite transmission; Plasmodium falciparum; priority journal; quantitative analysis; respirometry; RNA extraction; RNA translation; solid phase microextraction; supernatant; upregulation; animal; blood; drug effects; female; gene expression regulation; genetics; human; malaria falciparum; metabolism; mosquito vector; oocyte development; parasitology; physiology; volatilization; Anopheles gambiae; Plasmodium falciparum; Animals; Anopheles gambiae; Carbon Dioxide; Erythrocytes; Feeding Behavior; Female; Gene Expression Regulation; Humans; Malaria, Falciparum; Mosquito Vectors; Oogenesis; Organophosphates; Plasmodium falciparum; Terpenes; Transcription, Genetic; Volatilization
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243614
作者单位	Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, SE 106 91, Sweden; Unit of Chemical Ecology, Department of Plant Protection Biology, SLU, Alnarp, SE 230 53, Sweden; Department of Chemistry, Organic Chemistry, Royal Institute of Technology, Stockholm, SE 100 44, Sweden; Laboratory of Chemical and Behavioral Ecology, Institute of Ecology, Nature Research Centre, Vilnius, LT-08412, Lithuania; Department of Zoology, Stockholm University, Stockholm, SE 106 91, Sweden
推荐引用方式 GB/T 7714	Emami S.N.,Lindberg B.G.,Hua S.,et al. A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection[J],2017,355(6329).
APA	Emami S.N..,Lindberg B.G..,Hua S..,Hill S.R..,Mozuraitis R..,...&Faye I..(2017).A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection.Science,355(6329).
MLA	Emami S.N.,et al."A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection".Science 355.6329(2017).